You Searched For: (1R)-Camphor+oxime

Catalog Number: (89160-872)

Supplier: Enzo Life Sciences

Description: Serotonin receptor ligand

Catalog Number: (10073-126)

Supplier: Prosci

Description: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

Catalog Number: (89415-454)

Supplier: Prosci

Description: IRAK-M Antibody: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.

Supplier: Thermo Scientific Chemicals

Description: An aminoglycoside antibiotic derived from Kanamycin A.

Certificates

Catalog Number: (89150-426)

Supplier: Enzo Life Sciences

Description: Antibiotic

Catalog Number: (76100-418)

Supplier: Bioss

Description: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Catalog Number: (10068-872)

Supplier: Prosci

Description: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

Catalog Number: (89415-716)

Supplier: Prosci

Description: SIGIRR Antibody: SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

Catalog Number: (CA10759-304)

Supplier: Biolegend

Description: Brilliant Violet 711™ anti-mouse CD115 (CSF-1R) [AFS98]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC; Size: 50 μg

Supplier: Enzo Life Sciences

Description: GEF inhibitor

Supplier: Enzo Life Sciences

Description: Precursor to 1α,25-dihydroxyvitamin D₃

Catalog Number: (10749-308)

Supplier: Prosci

Description: MYD88 Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kappa B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

Supplier: Enzo Life Sciences

Description: Shikonin inhibits TNF-α- and B6 melanoma-induced angiogenesis in mice. It blocks expression of integrin αvβ3 and inhibits endothelial cell proliferation and migration in vitro.

Supplier: TCI America

Description: (stabilized with MEHQ)
CAS Number: 7534-94-3
MDL Number: MFCD00081070
Molecular Formula: C14H22O2
Molecular Weight: 222.33
Purity/Analysis Method: >85.0% (GC)
Form: Clear Liquid
Boiling point (°C): 129
Flash Point (°C): 144
Specific Gravity (20/20): 0.98

SDS Certificates

Supplier: TCI America

Description: CAS Number: 174813-82-2
MDL Number: MFCD12545951
Molecular Formula: C30H33ClN2O2RuS
Molecular Weight: 622.19
Purity/Analysis Method: >90% (HPLC)
Form: Crystal
Color: Yellow

SDS Certificates

Supplier: Thermo Scientific Chemicals

Description: Interacts with the immunophilins cyclophilin and FKBP-12

Certificates