AASTY 11-50

Supplier: CUBE BIOTECH

18266 18267 18265

77392-548PK 6545.4 CAD

77392-548 77392-544 77392-546

AASTY 11-50

AASTY 11-50

AASTYs (Acrylic acid-co-styrenes) - like AASTY 11-50 - are highly-alternating copolymers, well-suited for the generation of native lipid nanodiscs. They are a 2022 novel developed series for membrane protein solubilization & stabilization. AASTY 11-50 gets its name from its molecular weight and Acrylic Acid : Styrene Ratio. These varying ratios of acrylic acid to styrene contribute to the hydrophilic properties of our AASTYs. In general lighter AASTYs, like 6-45 tend to be more aggressive, while heavier AASTYs, such as 11-50 show higher thermodynamic stability.

Every membrane protein solubilization needs to undergo a screening process in before. The characteristic phospholipid environment surrounding the different membrane proteins in question performs differently well with each polymer. To support you in this process, we offer a handy Screening Kit for AASTYs to test them all.

We recommend the two following publications if you would like to get further information: Smith et al. 2020 & Timcenko et al. 2022

State: Lyophilized Powder, to be solved with water
Molecular weight: 10-11 kDa
Buffer: HEPES
pH after solving: 7.5
Divalent cationic tolerance: 6 mM
Acrylic Acid to Styrene Ratio: 50% to 50%

Caution: Shipping Temperature: Ambient temperature. Storage of lyophilized copolymer: -20°C for several years. Storage of dissolved copolymer: 2-8°C for several day.

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