SARS-CoV-2 Recombinant SARS CoV-2 Spike Protein Nanodisc Complex (from HEK293 cells)

Supplier: CUBE BIOTECH

SARS-CoV-2 Recombinant SARS CoV-2 Spike Protein Nanodisc Complex (from HEK293 cells)

SARS-CoV-2 Recombinant SARS CoV-2 Spike Protein Nanodisc Complex (from HEK293 cells)

29301 29303

77392-876EA 2818.47 CAD

77392-876 77392-878

SARS-CoV-2 Recombinant SARS CoV-2 Spike Protein Nanodisc Complex (from HEK293 cells)

Proteins and Peptides

The coronavirus, also known as SARS-CoV-2, enters the cell by using its surface SPIKE. SPIKE is processed on the cell's surface by TMPRSS2, a serine protease. It then subsequently binds to ACE2 a cell surface receptor.

Alternative names: SPIKE_SARS2 Spike glycoprotein
UniProt Number: P0DTC2
Protein class: Single span transmembrane protein
Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Sequence, explained: Full-length sequence (aa 1 - 1273), furin cleavage site 'RRAR' mutated to 'GSAG'; C-terminal Rho1D4 tag fused with spacer 'GSSG' to protein sequence
Affinity tags: C-terminal Rho1D4-tag
Expression host: Hek293 Expi cells
Buffer composition: 20 mM Hepes pH 7.5; 150 mM NaCl
Stabilizing MSP nanodisc: MSP1D1-His, assembly with POPC lipids (Membrane scaffold protein based nanodisc; MSP1D1 = 253 kDa)
Purified via: PureCube Rho1D4 Agarose
Function: Host cell surface receptor binding; fusion of virus membrane with host endosome membrane

The Native SPIKE protein is a trimer that is located in the coronavirus membrane. Therefore to get pure & native SPIKE this trimer needs to be kept intact. And Cube Biotech offers stabilized intact form of SPIKE.

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