SARS-CoV-2 Recombinant SARS-CoV-2 Spike Protein in SMALP 140 (from HEK293 cells)

Supplier: Cube Biotech
28711
77392-862EA 2893.52 CAD
77392-862
SARS-CoV-2 Recombinant SARS-CoV-2 Spike Protein in SMALP 140 (from HEK293 cells)
Proteins and Peptides
The coronavirus, also known as SARS-CoV-2, enters the cell by using its surface SPIKE. SPIKE is processed on the cell's surface by TMPRSS2, a serine protease. It then subsequently binds to ACE2 a cell surface receptor.

  • Alternative names: SPIKE_SARS2 Spike glycoprotein
  • UniProt Number: P0DTC2
  • Protein class: Single span transmembrane proteiN
  • Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
  • Sequence, explained: Full-length sequence (aa 1 – 1273), furin cleavage site 'RRAR' mutated to 'GSAG'; C-terminal Rho1D4 tag fused with spacer 'GSSG' to protein sequence
  • Affinity tags: C-terminal Rho1D4-tag
  • Buffer composition: 20 mM Hepes pH 7.5; 150 mM NaCl, buffer does not contain free SMALP 140
  • Stabilization agent: SMALP 140
  • Purified via: PureCube Rho1D4 Agarose
  • Function: Host cell surface receptor binding; fusion of virus membrane with host endosome membrane

The Native SPIKE protein is a trimer that is located in the coronavirus membrane. Therefore to get pure & native SPIKE this trimer needs to be kept intact. And Cube Biotech offers stabilized intact form of SPIKE.
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