Anti-Pan-TRK Rabbit Polyclonal Antibody

Supplier: Diagnostic Biosystems

RP176-01-RUO RP176-05-RUO RP176-RUO

CA76635-198EA 103.85 CAD

CA76635-198 CA76635-200 CA76635-202

Anti-Pan-TRK Rabbit Polyclonal Antibody

Antibodies

Neurotrophic tyrosine kinase receptor (NTRK) is a family of 3 proto-oncogenes including NTRK1, NTRK2, and NTRK3 which encode Trk A, Trk B, and Trk C proteins, respectively. The latter are involved in biological processes such as neuronal survival, differentiation, and plasticity under physiological circumstances. In various cancers, oncogenic fusions involving the kinase domain of NTRK1, 2, or 3 are present. Pan-Trk IHC is a time- and tissue-efficient screen for NTRK fusions, particularly in drivernegative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma. Pan-Trk IHC can help determine whether translation occurs for novel NTRK rearrangements.

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