Anti-Phosphohistone H3 (PHH3) Rabbit Polyclonal Antibody

Supplier: Diagnostic Biosystems

RP168-05-RUO RP168-RUO RP168-01-RUO

CA76635-176EA 355.18 CAD

CA76635-176 CA76635-178 CA76635-174

Anti-Phosphohistone H3 (PHH3) Rabbit Polyclonal Antibody

Antibodies

Phosphohistone H3 (PHH3) is a core histone protein, which together with other histones, forms the major protein constituents of the chromatin in eukaryotic cells. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis.Immunohistochemical studies showed anti-PHH3 specifically detected the core protein histone H3 only when phosphorylated at serine 10 or serine 28. Studies have also revealed no phosphorylation on the histone H3 during apoptosis.PHH3 can serve as a mitotic marker to separate mitotic figures from apoptotic bodies and karyorrhectic debris, which may be a very useful tool in diagnosis of tumor grades, especially in CNS, skin, gyn., soft tissue, and GIST.

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