Anti-A20 (A-12) Mouse Monoclonal Antibody [clone: A-12]

Supplier: Diagnostic Biosystems

MOB598-01-RUO MOB598-05-RUO MOB598-RUO

CA76634-246EA 260.61 CAD

CA76634-246 CA76634-248 CA76634-250

Anti-A20 (A-12) Mouse Monoclonal Antibody [clone: A-12]

Antibodies

A20 Antibody (A-12) is a high quality monoclonal A20 antibody (also designated TNFAIP3 antibody, or TNF a induced protein 3 antibody). A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1) and acts as a negative regulator of nuclear factor kB (NFkB) gene expression. By inhibiting NFkB activation, A20 plays a critical role in terminating NFkB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFkB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) g protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.

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