Anti-BCL2 Oncoprotein Mouse Monoclonal Antibody [clone: 124]

Supplier: Diagnostic Biosystems

MOB005-01-RUO MOB005-05-RUO MOB005-RUO

CA76633-098EA 144.79 CAD

CA76633-098 CA76633-100 CA76633-102

Anti-BCL2 Oncoprotein Mouse Monoclonal Antibody [clone: 124]

Antibodies

This antibody recognizes a protein of 25-26kDa, identified as bcl-2 alpha oncoprotein. It shows no cross-reaction with BCL-X or BAX protein. Expression of BCL-2 alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. This antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express BCL-2 protein and small number in which neoplastic cells are BCL-2 negative.

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