Human (Gln22/Asn23)-Amyloid B-Prot Trifluoroacetate

Supplier: BACHEM AMERICAS INC

4089804.0500 4089804.1000
10796-830EA 710.19 CAD
10796-830 10796-832
Human (Gln22/Asn23)-Amyloid B-Prot Trifluoroacetate
Proteins and Peptides

Transgenic mice expressing the vasculotropic Dutch/Iowa (E693Q/D694N) mutant human Aβ precursor protein in brain (Tg-SwDI) accumulate abundant cerebral microvascular fibrillar amyloid deposits and exhibit robust neuroinflammation. In vitro, the doubly mutated Aβ peptides showed an increased propensity to fibrillation and pathogenicity compared to the Dutch and Iowa single mutants.

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