Human (Gln22/Asn23)-Amyloid B-Prot Trifluoroacetate
Supplier: BACHEM AMERICAS INC
4089804.0500
4089804.1000
10796-830EA
710.19
CAD
10796-830
10796-832
Human (Gln22/Asn23)-Amyloid B-Prot Trifluoroacetate
Proteins and Peptides
Transgenic mice expressing the vasculotropic Dutch/Iowa (E693Q/D694N) mutant human Aβ precursor protein in brain (Tg-SwDI) accumulate abundant cerebral microvascular fibrillar amyloid deposits and exhibit robust neuroinflammation. In vitro, the doubly mutated Aβ peptides showed an increased propensity to fibrillation and pathogenicity compared to the Dutch and Iowa single mutants.
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