Anti-NNOS Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Anti-NNOS Rabbit Polyclonal Antibody

Anti-NNOS Rabbit Polyclonal Antibody

BML-SA227-0025 BML-SA227-0100

89162-746EA 249.64 CAD

89162-746 89162-748

Anti-NNOS Rabbit Polyclonal Antibody

Antibodies

The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin follo wing elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucose-sensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation.

For Immunocytochemistry, Western Blot

Recognizes human, mouse and rat nNOS.

Type: Primary
Antigen: NNOS
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human

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