Ac-Leu-Leu-Nle-CHO

Supplier: Enzo Life Sciences

Ac-Leu-Leu-Nle-CHO

Ac-Leu-Leu-Nle-CHO

BML-P120-0005 BML-P120-0025

89160-952EA 183.28 CAD

89160-952 89160-954

Ac-Leu-Leu-Nle-CHO

Proteins and Peptides

Cysteine protease inhibitor

Cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190nM), calpain II (Ki=150nM), cathepsin L (Ki=0.5nM) and other neutral cysteine proteases. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also stimulates HMG-CoA synthase transcription by inhibiting degradation of active SREBP-1 (sterol regulatory element-binding protein 1). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also prevents nitric oxide production by activated macrophages by interfering with the transcription of inducible nitric oxide synthase (iNOS; NOS II). Inhibits proteolytic degradation of IκBα and IκBß in RAW macrophages induced with LPS. It also prolong association of MHC class I molecules with the transporters associated with antigen processing.

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