ICRF-193 ≥95% (by HPLC)

Supplier: Enzo Life Sciences

Synonyms: Meso-4,4'-(3,2-butanediyl)-bis(2,6-piperazinedione)

BML-GR332-0001 BML-GR332-0005
89158-948EA 259.12 CAD
89158-948 89158-950
ICRF-193 ≥95% (by HPLC)
ICRF-193

A topoisomerase II inhibitor that does not cause DNA damage. Induces apoptosis in several cell lines including K562 and Molt-4 cells. Induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation.


  • Topoisomerase inhibitor


Off-white to pale yellow solid.


Soluble in DMSO (4mg/ml).

Formula: C₁₂H₁₈N₄O₄
MW: 282.3 g/mol
Melting Pt: 298…299 °C
Storage Temperature: Freezer
CAS Number: 21416-68-2
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