scriptaid ≥97% (by TLC)
Supplier: Enzo Life Sciences
Synonyms:
6-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanamide
HDAC inhibitor
Inhibitor of histone deacetylase (HDAC) (HDAC1 and 3: IC50~0.6µM; HDAC8: IC50~1µM) with lower toxicity than trichostatin A (Prod. No. BML-GR309). Inhibits tumor growth in vitro and in vivo and, in conjunction with 5-aza-2’-deoxycytidine (Prod. No. ALX-480-096), enhances expression of estrogen receptor α. Optimal concentration 2-2.5μg/ml (6-8μM). A negative control is available (Prod. No. BML-GR327).
Formula:
C₁₈H₁₈N₂O₄ MW: 326.352 g/mol |
MDL Number:
MFCD00386477 CAS Number: 287383-59-9 |
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