Dorsomorphin ≥98% (by TLC)

Supplier: Enzo Life Sciences

Dorsomorphin ≥98% (by TLC)

Dorsomorphin ≥98% (by TLC)

Synonyms: 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine, 6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

BML-EI369-0005 BML-EI369-0025

89158-206EA 180.12 CAD

89158-206 89158-208

Dorsomorphin ≥98% (by TLC)

Dorsomorphin

Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.

AMPK inhibitor

Yellow solid.

Soluble in DMSO (3mg/ml, warm)

Formula: C₂₄H₂₅N₅O
MW: 399.5 g/mol
Storage Temperature: Freezer

MDL Number: MFCD08705402
CAS Number: 866405-64-3

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