Staurosporine ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Staurosporine ≥98% (by HPLC)

Staurosporine ≥98% (by HPLC)

Synonyms: (5S,6R,7R,9R)-6-Methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one, Antibiotic AM-2282

380-014-C250 380-014-M001 380-014-M005

89149-816EA 237 CAD

89149-816 89149-818 89149-820

Staurosporine ≥98% (by HPLC)

Staurosporine

Apoptosis inducer

Model apoptosis inducer. Potent cell-permeable inhibitor of a variety of protein kinases, e.g. protein kinase C (PKC), CDK1/cyclin B (IC50~5nM), CDK2/cyclin A (IC50=7nM), CDK4/cyclin D (IC50=3-10µM), CDK5/p25 (IC50=4nM), GSK-3β (IC50=15nM), Pim-1 kinase (IC50=10nM).Binds do the ATP binding domain. Did not inhibit PKC-ζ. At 1µM induced apoptosis in CHO cells. Inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine.

Isolated from Streptomyces staurosporeus.

Protein kinase inhibitor.

Formula: C₂₈H₂₆N₄O₃
MW: 466.541 g/mol

MDL Number: MFCD18252446
CAS Number: 62996-74-1

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