ABT-888 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

ABT-888 ≥98% (by HPLC)

ABT-888 ≥98% (by HPLC)

Synonyms: (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide dihydrochloride, Veliparib 2HCl

270-444-M001 270-444-M005

89147-920EA 150.1 CAD

89147-920 89147-922

ABT-888 ≥98% (by HPLC)

ABT-888

PARP inhibitor

Potent inhibitor of PARP-1 and PARP-2 (potency ≤5nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radiopotentiation. Is toxic to both oxic and hypoxic cells. Enantiomeric purity ≥97% suitable for in vivo studies. Does not show inherent cytotoxicity and shows no single agent activity in tumor models. Has excellent bioavailability and good blood-brain permeation. Increases tumor growth delay resulting from radiation and DNA-damaging agents.

Formula: C₁₃H₁₈Cl₂N₄O
MW: 317.214 g/mol

MDL Number: MFCD12407402
CAS Number: 912445-05-7

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