L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethylester

Supplier: BACHEM AMERICAS INC

4027911.0001 4027911.0005

N-1650.0001BAEA 335.5 CAD

N-1650.0001BA N-1650.0005BA

L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethylester

Proteins and Peptides

E64d (EST), a membrane permeable analog of E64c, was expected to be useful as an oral drug for muscular dystrophy due to its potent inhibitory activities against the cysteine proteinases involved in the myofibrillar protein degradation that occurs in this disease. E64d attenuates the effects of parathyroid hormone on osteoblasts in vitro. By inhibiting cathepsin B, a cysteine protease showing β-secretase activity, E64d could reduce brain Aβ and improve memory deficits in Alzheimer's disease animal models.

Bachem additionally offers deuterated and ¹⁵N-labeled leucine: Fmoc-[D₁₀]Leu-OH (B-4120) and Fmoc-[¹⁵N]Leu-OH (B-2655).

Commonly used protease inhibitors as bestatin and the E-64s are derived from leucine. See also H-Leu-NH₂ (E-2650) and Z-Leu-ONp (C-2120).

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