Fmoc-L-4-azidophe
Supplier: BACHEM AMERICAS INC
Synonyms:
Fmoc-p-azido-Phe-OH
Sequence: Fmoc-p-azido-Phe-OH
Bachem offers a considerable choice of ring-substituted phenylalanines, protected derivatives of: p-Aminophenylalanine p-Azidophenylalanine p-Benzoylphenylalanine p-Biphenylalanine p-Bromophenylalanine p-t-Butylphenylalanine p-Carboxyphenylalanine p-Chlorophenylalanine p-Cyanophenylalanine 3,4-Dichlorophenylalanine Fluorophenylalanines p-Iodophenylalanine p-Methylphenylalanine p-Nitrophenylalanine p-Phosphonophenylalanine. p-Methoxy- and p-ethoxyphenylalanine derivatives are listed in the Tyr family, whereas β,β-diphenylalanine derivatives can be found in the "β-Substituted Alanines" family.
For further azido compounds suitable as photolabels or for 1,3-dipolar cycloaddition / click chemistry please see Q-1995 (3-(4-Azidophenyl)propionic acid), Q-2005 (4-(4-Azidophenyl)butyric acid and Q-2725 (5-Azido-pentanoic acid). Azido-functionalized amino acid derivatives are also on offer: Fmoc-Dab(N₂)-OH (B-4145), Fmoc-Orn(N₂)-OH (B-4140), Fmoc-Lys(N₂)-OH (B-4135), Boc-Orn(N₂)-OH · DCHA (A-4770), and Boc-Lys(N₂)-OH · DCHA (A-4765).
The azido group is sensitive towards piperidine. In Fmoc-SPPS, this derivative is best introduced as N-terminus or modified before elongating the peptide. B-2360 has been employed as a precursor of p-aminophenylalanine. Levinson et al. reduced the azido group on-resin with a large excess of tributylphosphine in DMF.
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Formula:
C₂₄H₂₀N₄O₄ MW: 428.448 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00237665 CAS Number: 163217-43-4 |
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