Human TRAP-6 Trifluoroacetate
Supplier: BACHEM AMERICAS INC
PAR peptides (TRAP peptides and thrombin receptor-like peptides) activate the proteinase-activated receptors PAR-1 to PAR-4.
PAR-1 peptides are also called TRAP peptides (thrombin receptor-activating peptides).
SFLLRN corresponds to residues 42-47 of the thrombin receptor. The hexapeptide acts as a thrombin receptor activator. It caused half-maximal platelet aggregation at approx. 0.8 µM and was 5 times more potent than the parent peptide H-8105. In addition, SFLLRN is effective in causing tyrosine phosphorylation, inhibition of cAMP formation, and an increase in cytosolic Ca²⁺.
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