Human;Mouse H-Tyr-Ile-Gly-Ser-Arg-OH Trifluoroacetate

Supplier: BACHEM AMERICAS INC

4011700.0005 4011700.0025
H-6825.0005BAEA 264.4 CAD
H-6825.0005BA H-6825.0025BA
Human;Mouse H-Tyr-Ile-Gly-Ser-Arg-OH Trifluoroacetate
Proteins and Peptides

The pentapeptide YIGSR located within domain III of the laminin B1 chain, represents a major receptor binding site in laminin. By competing with laminin for the cell surface receptor, the short peptide is able to inhibit cell attachment to basement membranes, thus preventing the formation of tumor metastases. YIGSR also promotes tumor cell migration and, moreover, mediates the adhesion of a variety of epithelial cells to laminin.

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