(Lys²²)-beta-Amyloid (1-40) Trifluoroacetate

Supplier: BACHEM AMERICAS INC

4049003.0500 4049003.1000
H-6698.0500BAEA 750.07 CAD
H-6698.0500BA H-6698.1000BA
(Lys²²)-beta-Amyloid (1-40) Trifluoroacetate
Proteins and Peptides

The Italian mutation of β-amyloid 1-40 (E22K) aggregates more rapidly than the wild-type sequence 1-40. It showed increased neurotoxicity, which (according to a solid-phase NMR-study of Masuda et al.) may be due to the salt bridge formed between Lys²² and Asp²³ in the minor conformer. As the Arctic, Flemish, and Dutch mutants, the Italian mutant is degraded considerably more slowly than wild-type Aβ by neprilysin.

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