Tyr-(D-Dab⁴,Arg⁵,D-Trp⁸)-Cyclo-Somatostatin-14 (4-11) Trifluoroacetate

Supplier: BACHEM AMERICAS INC

4041674.0001 4041674.0005

H-6276.0001BAEA 794.35 CAD

H-6276.0001BA H-6276.0005BA

Tyr-(D-Dab⁴,Arg⁵,D-Trp⁸)-Cyclo-Somatostatin-14 (4-11) Trifluoroacetate

Proteins and Peptides

High affinity ligand for all five somatostatin receptors (sst1-sst5). In AtT-20 mouse anterior pituitary tumor cells which mainly express sst2 and sst5 receptors the binding affinity of this somatostatin analog was found to be higher than that of somatostatin-14 (H-1490) and octreotide (H-5972). In a model of epileptogenesis, however, KE 108 did not exhibit antiepileptic activity suggesting that the high potency and efficacy of a synthetic ligand to all known somatostatin receptors may not reproduce entirely the effects of the natural ligand.

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