Mouse;Rat (2-Furoyl)-PAR-2 (2-6)-Orn amide Trifluoroacetate

Supplier: BACHEM AMERICAS INC

4048620.0005 4048620.0025

H-6246.0005BAEA 645.43 CAD

H-6246.0005BA H-6246.0025BA

Mouse;Rat (2-Furoyl)-PAR-2 (2-6)-Orn amide Trifluoroacetate

Proteins and Peptides

PAR peptides (TRAP peptides and thrombin receptor-like peptides) activate the proteinase-activated receptors PAR-1 to PAR-4.

2-(2-Furoyl)-PAR-2 (2-6)-Orn amide (mouse, rat) is a potent and selective PAR-2 agonist. In cultured human PAR-2-expressing cells (2-Furoyl)-LIGRLO-amide was equally effective as SLIGRL-amide (H-5078), in rat PAR-2-expressing cells it was 10 to 25 times more potent than SLIGRLamide in increasing intracellular calcium levels. In bioassays of tissue PAR-2 activity, measured as arterial vasodilation and hyperpolarization this agonist was 10 to 300 times more potent than H-5078.

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