Cecropin A (1-7)-Melittin A (2-9) amide Trifluoroacetate

Supplier: BACHEM AMERICAS INC

4042609.0001 4042609.0005

H-5948.0001BAEA 430.77 CAD

H-5948.0001BA H-5948.0005BA

Cecropin A (1-7)-Melittin A (2-9) amide Trifluoroacetate

Proteins and Peptides

Antimicrobial peptides are produced by plants and most organisms throughout the animal kingdom including humans. Antimicrobial peptides protect against a broad range of infectious agents, as bacteria, fungi, and viruses. The amphibian skin is an especially rich source of antimicrobial peptides. See also the product families: Hepcidins LL-37 and Fragments Tuftsin and Analogs (subfamily).

The cecropins are a group of antibacterial peptides that were first isolated from the hemolymph of the giant silk moth Hyalophora cecropia.

Cecropin A (1-7)-Melittin A (2-9) amide, also referred to as CAMEL0, is a synthetic hybrid peptide that is composed of portions of the naturally occurring antibiotic peptide cecropin A and melittin. CAMEL0 shows a better antimicrobial activity than the native molecules, but lacks the hemolytic properties of melittin. Studies revealed that the range of its antimicrobial activity is not only restricted to aerobic microorganisms but also included several gram-negative and gram-positive anaerobic microorganisms. Through its ascertained broad spectrum of antibiotic activity, this hybrid peptide may also represent an effective substitute for ciprofloxacin in the treatment of anthrax infections.

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