Human Proadrenomedullin (1-20)

Supplier: BACHEM AMERICAS INC

4034490.0500 4034490.1000
H-4916.0500BAEA 516.34 CAD
H-4916.0500BA H-4916.1000BA
Human Proadrenomedullin (1-20)
Proteins and Peptides

Proadrenomedullin, the precursor of adrenomedullin, contains a unique 20-residue sequence termed proadrenomedullin NH₂-terminal 20 peptide (PAMP). The i.v. administration of PAMP produces a rapid and strong hypotensive effect in anesthetized rats. It has been suggested, that PAMP functions as an inhibitory modulator of renal noradrenergic neurotransmission and plays an important role in regulating renal functions. Furthermore, it has been suggested that PAMP can act as an inhibitory regulator of adrenal catecholamine release in vivo and has a potent hyperglycemic effect after intra-third cerebroventricular administration in fasted mice.

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