Human PAR-4 (1-6) Trifluoroacetate, Bachem

Supplier: BACHEM AMERICAS INC

4028678.0005 4028678.0025
H-4348.0005BAEA 264.68 CAD
H-4348.0005BA H-4348.0025BA
Human PAR-4 (1-6) Trifluoroacetate, Bachem
Proteins and Peptides

PAR peptides (TRAP peptides and thrombin receptor-like peptides) activate the proteinase-activated receptors PAR-1 to PAR-4.


The hexapeptide GYPGQV corresponding to the amino terminus of the fourth protease-activated receptor (PAR4) after the cleavage at Arg⁴⁷/Gly⁴⁸ was tested for its ability to stimulate COS cells expressing PAR4. GYPGQV readily activated both wild-type and mutant PAR4 (R47A) at 500 µM, whereas thrombin and trypsin only activate the wild-type PAR4.

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