Human Orexin B Trifluoroacetate, Bachem

Supplier: BACHEM AMERICAS INC

4028263.0500 4028263.1000 4028263.5000
H-4174.0500BAEA 593.81 CAD
H-4174.0500BA H-4174.1000BA H-4174.5000BA
Human Orexin B Trifluoroacetate, Bachem
Proteins and Peptides

Like orexin A, orexin B (OXB) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of OXB to rats stimulated food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX₁ receptor is significantly lower (IC₅₀ = 240 nM) than that of orexin A. Binding affinities for the OX₂ receptor are similar for orexin A and B (IC₅₀ = 38 nM and 36 nM, respectively, for displacement of radiolabeled orexin A bound to the receptor).

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