Bovine;Guinea pig;Human;Mouse;Pig;Rat GLP-1 (9-36) Amide Trifluoroacetate

Supplier: BACHEM AMERICAS INC

4027697.0001 4027697.0005

H-4012.0001BAEA 1145.93 CAD

H-4012.0001BA H-4012.0005BA

Bovine;Guinea pig;Human;Mouse;Pig;Rat GLP-1 (9-36) Amide Trifluoroacetate

Proteins and Peptides

For the long-acting GLP-1 analog liraglutide see H-6724.

Glucagon-like peptide-1 (GLP-1) is efficiently degraded by the enzyme dipeptidyl peptidase IV (DPP IV), yielding the major metabolite GLP-1 (9-36) amide. GLP-1 (9-36) amide does not affect glucose disposal in mice either in the presence or absence of intact GLP-1 receptors or in the presence or absence of stimulated insulin levels. This suggests that the GLP-1 metabolite is not involved in the regulation of glucose homeostasis. Elahi et al. have shown that this GLP-1 metabolite acts as a weak insulinotropic agent and inhibits hepatic glucose production.

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