H-His-Cys-Lys-Phe-Trp-Trp-OH

Supplier: BACHEM AMERICAS INC

4026848.0005 4026848.0025
H-3524.0005BAEA 317.52 CAD
H-3524.0005BA H-3524.0025BA
H-His-Cys-Lys-Phe-Trp-Trp-OH
Proteins and Peptides

HCKFWW, potent inhibitor of the HIV-encoded integrase (IN), the enzyme responsible for the integration of HIV DNA into the human genome. HCKFWW inhibits IN-mediated 3'processing and integration with an IC₅₀ of 2 µM. The peptide is also active on IN proteins from other retroviruses such as HIV-2, feline immunodeficiency virus and Moloney murine leukemia virus. It was also found to inhibit the disintegration reaction, suggesting that this hexapeptide acts at or near the catalytic site of IN.

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