Cyclo(-Leu-Phe)

Supplier: BACHEM AMERICAS INC

4025585.0250 4025585.1000

G-4385.0250BAEA 317.52 CAD

G-4385.0250BA G-4385.1000BA

Cyclo(-Leu-Phe)

Proteins and Peptides

Also known as dioxopiperazines, piperazine-2,5-diones or DKPs. Diketopiperazines may occur as by-products during peptide synthesis or during the degradation of peptides. These cyclic dipeptides have been detected as taste-modulating compounds in food, they often show biological activity. DKPs are valuable chiral synthons, employed e.g. in Schöllkopf's versatile bislactim ether approach. They also have found use as catalysts for enantioselective synthesis, e.g. in the asymmetric Strecker reaction. See also the TRH metabolite cyclo(-His-Pro), G-1745, and cyclo(-Asp-Phe), G-1695, the major degradation product of aspartame.

This diketopiperazine is converted into the antibacterial dehydropeptide albonoursin by cyclo(Leu-Phe) oxidase from S. albulus KO-23.

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