Human Synthetic DCD-1L Trifluoroacetate

Supplier: BACHEM AMERICAS INC

4061590.0500
H-7316.0500BAEA 2178.76 CAD
H-7316.0500BA
Human Synthetic DCD-1L Trifluoroacetate
Proteins and Peptides

The protein dermcidin expressed in the sweat glands is secreted into the sweat and transported to the epidermal surface. The concomitant processing of the protein yields a broad-spectrum antimicrobial 47 amino acid peptide, dermcidin-1 (DCD-1).


Dermcidin and naturally occurring fragments as DCD-1L do not perturb membrane permeability and bind to distinct surface molecules. It stimulates keratinocytes to generate cytokines and chemokines such as TNF-α, IL-8, CXCL10, and CCL20.


Sequence: H-Ser-Ser-Leu-Leu-Glu-Lys-Gly-Leu-Asp-Gly-Ala-Lys-Lys-Ala-Val-Gly-Gly-Leu-Gly-Lys-Leu-Gly-Lys-Asp-Ala-Val-Glu-Asp-Leu-Glu-Ser-Val-Gly-Lys-Gly-Ala-Val-His-Asp-Val-Lys-Asp-Val-Leu-Asp-Ser-Val-Leu-OH trifluoroacetate salt

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SPECIFICATIONS

Protein/peptide name DCD-1L Trifluoroacetate
Environmentally Preferable
Protein/peptide type Synthetic
Species Human
Source
CAS No. 478898-18-9
Sequence SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL
Molecular weight 4818.5 g/mol
Molecular formula C₂₁₀H₃₅₉N₅₇O₇₁
Storage conditions –20 ± 5 °C

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