BQ-788

Supplier: BACHEM AMERICAS INC

4026108.0001 4026108.0005
H-2492.0001BAEA 688.42 CAD
H-2492.0001BA H-2492.0005BA
BQ-788
Proteins and Peptides

Endothelins are peptides with exceptional vasoconstrictor potency. They play an important role in intercellular communications.


In vitro, BQ-788 potently and competitively inhibited ¹²⁵I-labeled ET-1 binding to ET-B receptors on human Girardi heart cells (IC₅₀= 1.2 nM). However, BQ-788 only poorly inhibited ET-1 binding to ET-A receptors on human neuroblastoma cell line SK-N-MC cells (IC₅₀= 1300 nM). Thus the ET-B receptor antagonist BQ788 may be considered as a powerful tool for investigating the role of ET in physiological and pathological processes.

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SPECIFICATIONS

Protein/peptide name BQ-788
Environmentally Preferable
Species
Source
CAS No. 173326-37-9
MDL No. MFCD06245594
Sequence N-cis-2,6-Dimethylpiperidinocarbonyl-β-tBu-Ala-D-Trp(1-methoxycarbonyl)-D-Nle-OH
Molecular weight 641.81
Molecular formula C₃₄H₅₁N₅O₇
Storage conditions –20 ± 5 °C

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