Anti-CDKN1A Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
PA512644
CAPIPA5-12644EA 3258.01 CAD
CAPIPA5-12644
Anti-CDKN1A Rabbit Polyclonal Antibody
Antibodies
p21 is a potent cyclin-dependent kinase inhibitor. It binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this protein is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. p21 can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. It wasMore Product Information
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