Anti-APP Rabbit Polyclonal Antibody

Supplier: Prosci
2133
89415-336EA 896.35 CAD
89415-336
Anti-APP Rabbit Polyclonal Antibody
Antibodies
APP Antibody: Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the brains of all suffers of Alzheimer's disease.

Type: Primary
Antigen: APP
Clonality: Polyclonal
Clone:
Conjugation:More Product Information
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SPECIFICATIONS

Antigen symbol APP
Antigen name amyloid beta (A4) precursor protein
Environmentally Preferable
Antigen synonyms APPA
Antibody type Primary
Clonality Polyclonal
Conjugation Unconjugated
Reactivity Human,Rat,Mouse
Host Rabbit
Gene ID P05067
Isotype IgG
Western blot Yes
ELISA Yes
ImmunoChemistry Yes
Immunogen APP antibody was raised against a peptide corresponding to 10 amino acids of human amyloid A4 protein precursor (APP) corresponding to the amino terminus of the 4K Ab peptide generated by beta- and gamma-secretases. The immunogen is located within amino acids 650 - 700 of APP.
Form Liquid
Molecular weight Predicted: 83 kDa Observed: 115 kDa
Purification APP Antibody is affinity chromatography purified via peptide column.
Concentration 1 mg/mL
Storage buffer APP Antibody is supplied in PBS containing 0.02% sodium azide.
Storage temperature APP antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Shipping temperature 4 °C
Tested applications E, WB, IHC

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