You Searched For: Prosci

Catalog Number: (10750-484)

Supplier: Prosci

Description: MATN3 Antibody: Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN3 is composed of a single N-terminal von Willebrand Factor A (vWFA) domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain whereas MATN1 is composed of two vWFA domains separated by one EGF-like domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that aberrant expression and processing of MATN3 are hallmarks of conventional cartilaginous neoplasms.

Catalog Number: (10750-496)

Supplier: Prosci

Description: MATN3 Antibody: Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN3 is composed of a single N-terminal von Willebrand Factor A (vWFA) domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain whereas MATN1 is composed of two vWFA domains separated by one EGF-like domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that aberrant expression and processing of MATN3 are hallmarks of conventional cartilaginous neoplasms.

Catalog Number: (10750-446)

Supplier: Prosci

Description: GNPDA2 Antibody: Glucosamine-6-phosphate deaminase (GNPDA) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. GNPDA2 is the second mammalian glucosamine-6-phosphate deaminase discovered, and is closer in structure and activity to the E. coli enzyme than GNPDA1. GNPDA1 possesses greater affinity for ammonium than either GNPDA2 or the E. coli enzyme suggesting that the forward reaction of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium is catalyzed at a slower rate than GNPDA2.

Catalog Number: (10750-436)

Supplier: Prosci

Description: CDIP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.

Catalog Number: (10750-464)

Supplier: Prosci

Description: LRFN5 Antibody: LRFN5 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while LRFN2 and LRFN5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system.

Catalog Number: (10116-578)

Supplier: Prosci

Description: Polyclonal; Host: Goat; Immunogen: RASSF1 antibody was raised against a 14 amino acid synthetic peptide near the internal region of RASSF1; Application: ELISA

Catalog Number: (10116-540)

Supplier: Prosci

Description: Polyclonal; Host: Goat; Species Reactiviy: Mouse; Immunogen: PTBP2 antibody was raised against an 11 amino acid synthetic peptide near the internal region of PTBP2; Application: ELISA, Western Blot

Catalog Number: (10116-568)

Supplier: Prosci

Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: RAE1 antibody was raised against a 12 amino acid synthetic peptide near the C-Terminus of RAE1; Application: ELISA, Western Blot, IHC

Catalog Number: (10116-618)

Supplier: Prosci

Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: RNF2 antibody was raised against a 13 amino acid synthetic peptide near the C-Terminus of RNF2; Application: ELISA, Western Blot

Catalog Number: (75794-472)

Supplier: Prosci

Description: IL-1beta is produced by activated macrophages. IL-1beta stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1beta belongs to the IL-1 family of proteins that are involved in the inflammatory response. IL-1beta in most situations requires the inflammasome complex to be cleaved and secreted.

Catalog Number: (10075-196)

Supplier: Prosci

Description: Polyclonal, Host: Rabbit; Species Reactivity: Human; Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 514 and 657 of TLR3; Tested Applications: ICC, IF, IHC, WB

Catalog Number: (10100-796)

Supplier: Prosci

Description: SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.

Catalog Number: (76629-440)

Supplier: Prosci

Description: Anti-Cd86 Recombinant Antibody [Clone: PO.3]

Catalog Number: (76629-598)

Supplier: Prosci

Description: Anti-Ptprc Recombinant Antibody [Clone: RA3-6B2]

Catalog Number: (76629-336)

Supplier: Prosci

Description: Anti-CD37 Recombinant Antibody [Clone: MB-1]

Catalog Number: (76630-066)

Supplier: Prosci

Description: Anti-INSR Recombinant Antibody [Clone: Fab 83-7]