Anti-CHK2 Thr68 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Supplier: Bioss

BS-3721R-A680
76084-776EA 1190.97 CAD
76084-776
Anti-CHK2 Thr68 Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Antibodies
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosineMore Product Information
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SPECIFICATIONS

Environmentally Preferable
Antigen name CHK2 Thr68
Antigen synonyms Cds1 homolog|PP1425|LFS2|CHK2 checkpoint homolog|RAD53|CDS1|hCds1|HuCds1|Checkpoint kinase 2|CHEK2|Serine/threonine-protein kinase Chk2|CHK2
Antibody type Primary
Clonality Polyclonal
Conjugation Alexa Fluor® 680
Reactivity Chicken,Human,Rat,Mouse
Host Rabbit
Gene ID 11200
Isotype IgG
Western blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Modification Phosphorylation (Thr68)
Immunogen KLH conjugated synthetic phosphopeptide derived from human CHK2 around the phosphorylation site of Thr68
Form Liquid
Molecular weight 61 kDa
Purification Purified by Protein A
Concentration 1 µg/µl
Storage buffer Aqueous buffered solution containing 0.01 M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage temperature Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Shipping temperature 4 °C
Tested applications ICC

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