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Description: PAK2 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6, and are not activated by Cdc42/Rac binding. Of the six PAK proteins, only PAK2 is ubiquitously expressed and cleaved by caspase-3. This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment. Recent experiments have shown that following cleavage, the active fragment is myristoylated and directed to the plasma membrane and membrane ruffles where it promotes cell death via increased signaling through the c-Jun N-terminal kinase pathway, but without compromising mitochondrial integrity.

Catalog Number: 89416-094

Supplier: Prosci

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Description: Sheep Polyclonal antibody to neuroserpin

Catalog Number: 89328-682

Supplier: Genetex

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Description: CAS Number: 88744-04-1
MDL Number: MFCD00013261
Molecular Formula: C21H11F5O3
Molecular Weight: 406.31
Purity/Analysis Method: >98.0% (HPLC)
Form: Crystal
Melting point (°C): 85
Lambda max.: 300 nm (EtOH)

Catalog Number: TCF0936-5G

Supplier: TCI America

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Description: Rabbit polyclonal antibody to SDS (N-terminal)

Catalog Number: 89270-256

Supplier: Genetex

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Description: CAMK1D is a serine?threonine kinase that is a member of the calcium?calmodulin-dependent protein kinase family

Catalog Number: 75791-034

Supplier: Prosci

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Description: This peptide sequence, RHDSGLDSMKD, is derived from the area surrounding serine 32 and serine 36 of IκBα, which is phosphorylated by IκB Kinase (IKK). The biotin allows the peptide to be used in IKK kinase assays with streptavidin-bound membranes.

Catalog Number: 89161-010

Supplier: Enzo Life Sciences

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Description: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA.

Catalog Number: 76080-034

Supplier: Bioss

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Description: Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

Catalog Number: 76118-058

Supplier: Bioss

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Description: Rabbit polyclonal to TMPRSS2 (Internal)

Catalog Number: 89302-074

Supplier: Genetex

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Description: Rabbit polyclonal antibody to SERC2

Catalog Number: 89290-126

Supplier: Genetex

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Description: Rabbit polyclonal antibody to SFRS2B

Catalog Number: 89290-564

Supplier: Genetex

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Description: Rabbit Polyclonal antibody to antithrombin III

Catalog Number: 89328-690

Supplier: Genetex

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Description: Goat polyclonal antibody to TMPRSS2

Catalog Number: 89296-630

Supplier: Genetex

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Description: Mouse Monoclonal antibody [4H12] to STK11

Catalog Number: 89291-680

Supplier: Genetex

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Description: Sheep Polyclonal antibody to neuroserpin (HRP)

Catalog Number: 89295-694

Supplier: Genetex

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Description: Rabbit polyclonal antibody to TSSK4

Catalog Number: 89289-874

Supplier: Genetex

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