You Searched For: BIOGEMS INTERNATIONAL INC.

Catalog Number: (75841-676)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains γ, δ, and ε subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 ε chain.

Catalog Number: (75841-990)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The A20 monoclonal antibody reacts with the leukocytes of the CD45.1-expressing mouse strains (DA, SJL/J, RIII, and STS/A). It does not cross-react with cells that express CD45.2. The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region’s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons. The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction. The A20 antibody inhibits some of the B lymphocytes responses, from CD45.1-expressing mice, to lipopolysaccharides and antigens. BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.

Catalog Number: (75842-160)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The TS2/16 moncolonal antibody specifically reacts with human CD29 (Integrin beta1), a 130 kDA type I glycoprotein expressed on hematopoietic and non-hematopoietic cells. It forms the VLA-(1-6) molecules with integrin alpha-(1-6) and is involved in the adhesion between cell-cell and cell-matrix. The TS2/16 antibody has been found to activate beta 1 integrins.

Catalog Number: (75842-136)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 1D3 monoclonal antibody specifically reacts with mouse CD19, a 95 kDa transmembrane glycoprotein, a member of the Ig superfamily and a B cell-lineage differentiation antigen expressed by all the B lymphocyte development stages, except for the terminally differentiated plasma cells. CD19 associates with CD21, CD81 and MHC class II to form a multi-molecular complex that initiates the mature B lymphocyte activation by interaction with the B-cell receptors. CD 19 enhances the B cell proliferation, development and activation, and the maturation of memory B cells. In CD19-deficient mice, the generation and maturation of B lymphocytes in the bone marrow and periphery are affected.

Catalog Number: (75842-088)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The OKT8 monoclonal antibody specifically reacts with human CD8α molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa. CD8α is a member of the Ig superfamily, expressed as a homodimer (CD8αα) or as a heterodimer (CD8αβ). CD8+ αβ T lymphocytes express both CD8αα and CD8αβ, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes.OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.

Catalog Number: (75842-130)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 1D3 monoclonal antibody specifically reacts with mouse CD19, a 95 kDa transmembrane glycoprotein, a member of the Ig superfamily and a B cell-lineage differentiation antigen expressed by all the B lymphocyte development stages, except for the terminally differentiated plasma cells. CD19 associates with CD21, CD81 and MHC class II to form a multi-molecular complex that initiates the mature B lymphocyte activation by interaction with the B-cell receptors. CD 19 enhances the B cell proliferation, development and activation, and the maturation of memory B cells. In CD19-deficient mice, the generation and maturation of B lymphocytes in the bone marrow and periphery are affected. BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.

Catalog Number: (75842-094)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The OKT8 monoclonal antibody specifically reacts with human CD8α molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa. CD8α is a member of the Ig superfamily, expressed as a homodimer (CD8αα) or as a heterodimer (CD8αβ). CD8+ αβ T lymphocytes express both CD8αα and CD8αβ, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes.OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.

Catalog Number: (75842-320)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 2B11 monoclonal antibody specifically reacts with mouse CD184 (CXCR4or Fusin), a seven-transmembrane G-protein-coupled receptor. It is expressed by astrocytes, B cells, T cells, monocytes, neutrophils, neurons, and hematopoietic cell types. CD184 is a coreceptor for X4 HIV-1.The monoclonal 2B11 antibody recognizes the amino terminus of CD184 and has functional activity.

Catalog Number: (75842-360)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 10F.9G2 monoclonal antibody specifically reacts with mouse CD274, also known as B7-H1 or PD-L1, a 43 kDa glycoprotein of the B7 family of the immunoglobulin superfamily. CD274 is expressed on the B and T lymphocytes, natural killer cells, and dendritic cells. The receptor for the B7-H1 molecule is PD-1, which contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), and is expressed on activated B and T cells. The interaction between CD274 and PD-1 seems to downregulate the T and B immune responses.

Catalog Number: (75842-376)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4). CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.

Catalog Number: (75842-354)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The TLR3.7 monoclonal antibody specifically reacts with human CD283 (TLR3), a type I transmembrane signaling receptor containing IL-1 receptor like intracellular domain and leucine-rich repeats (LRR) in the extracellular domain. It is expressed by dendritic cells and recognize double-stranded RNA and polyinosine-polycytidylic acid. Upon ligand binding, CD283 induces type I interferon production and activation of the nuclear factor kappa-light-chain-enhancer of activated B cells complex (NF-κB).

Catalog Number: (75842-368)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 10F.9G2 monoclonal antibody specifically reacts with mouse CD274, also known as B7-H1 or PD-L1, a 43 kDa glycoprotein of the B7 family of the immunoglobulin superfamily. CD274 is expressed on the B and T lymphocytes, natural killer cells, and dendritic cells. The receptor for the B7-H1 molecule is PD-1, which contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), and is expressed on activated B and T cells. The interaction between CD274 and PD-1 seems to downregulate the T and B immune responses.

Catalog Number: (75842-210)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The OV9A2 monoclonal antibody specifically reacts with human CD59 (Protectin), a 19-25 kDA GPI-anchored glycoprotein. CD59 is expressed on hematopoietic and non-hematopoietic cells including lymphocytes, granulocytes, erythrocytes, monocytes and neurons. CD59 can inhibit complement cytolytic activity and the assembly of the membrane attack complex when bound to C8 and C9 complement components. It is involved in T cell activation and modulates T cell adhesion through interaction with CD2.

Catalog Number: (75842-272)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 6H6 monoclonal antibody specifically reacts with human CD123, the alpha chain subunit of the IL-3 receptor. CD123’s affinity to IL-3 is low, but increases when associated with CD131. It can be found on basophils, dendritic cells, macrophages, and mast cells.

Catalog Number: (75842-248)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.

Catalog Number: (75842-738)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The 2H7 monoclonal antibody specifically reacts with human CD20, a 33-37kDA B-lymphocyte surface molecule. CD20 is an unglycosylated four-transmembrane phosphoprotein expressed by B cells in all stage of development, except the final plasma cells. It has been reported that the molecule is involved in B cell activation and has also been observed on a subset of circulating T lymphocytes.