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Catalog Number: (CAPIPA5-18770)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with human and mouse based on sequence homology. This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Catalog Number: (CAPIMA1014HRP)

Supplier: Thermo Scientific

Description: For Western Blot, this antibody has non-specific bands at 47 kDa and 75 kDa. This antibody is predicted to react with rat and chicken based on sequence homology. Core binding factor is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Catalog Number: (CAPIPA5-18756)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with human based on sequence homology. The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease , also known as Anderson disease . Two transcript variants encoding the same protein have been found for this gene.

Catalog Number: (CAPIPA5-15198)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, mouse, porcine and rat based on sequence homology. BDNF is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this protein is reduced in both Alzheimer's and Huntington disease patients. This protein may play a role in the regulation of stress response and in the biology of mood disorders.

Catalog Number: (CAPIPA526132)

Supplier: Thermo Scientific

Description: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. It lacks enzymatic (caspase) activity.

Catalog Number: (CAPIPA526629)

Supplier: Thermo Scientific

Description: STK40 may be a negative regulator of NF-kappa-B and p53-mediated gene transcription.

Catalog Number: (CAPIPA526743)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse and rat based on sequence homology. CACNA2D3 is a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits.

Catalog Number: (CAPIPA5-18586)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine, mouse and rat based on sequence homology. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase family. The protein encoded by this gene is a receptor for ephrin-B family members.

Catalog Number: (CAPIPA5-13399)

Supplier: Thermo Scientific

Description: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function.

Catalog Number: (CAPIPA5-18468)

Supplier: Thermo Scientific

Description: This gene encodes polytransferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.

Catalog Number: (CAPIPA5-17931)

Supplier: Thermo Scientific

Description: May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length.

Catalog Number: (CAPIPA525887)

Supplier: Thermo Scientific

Description: Host: Rabbit Species Reactivity: Human (Hu) Immunogen: Synthetic peptide from the C-terminal region of human TRAM2 conjugated to KLH.

Catalog Number: (CAPIPA5-18786)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse based on sequence homology.

Catalog Number: (CAPIPA5-16801)

Supplier: Thermo Scientific

Description: PA5-16801 targets Alpha Fetoprotein in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-16801 immunogen is human alpha-fetoprotein purified from human cord serum. AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.

Catalog Number: (CAPIPA5-18919)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with rat based on sequence homology. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Catalog Number: (CAPIPA5-13364)

Supplier: Thermo Scientific

Description: Mutations in TSC2 lead to tuberous sclerosis complex. This protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. It may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.