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Catalog Number: (CAPIPA5-18556)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine, human and rat based on sequence homology. The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.

Catalog Number: (CAPIPA5-15094)

Supplier: Thermo Scientific

Description: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK8 is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. The protein appears to play an important role in the cell cycle. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.

Catalog Number: (CAPIPA5-12383)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine based on sequence homology. GADD45A responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45A gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.

Catalog Number: (CAPIPA5-18275)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine and rat based on sequence homology. This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined.

Catalog Number: (CAPIPA5-18718)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine, mouse and rat based on sequence homology. Nuclear factor of activated T-cells is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.

Catalog Number: (CAPIPA5-18919)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with rat based on sequence homology. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Catalog Number: (CAPIPA5-14488)

Supplier: Thermo Scientific

Description: The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.

Catalog Number: (CAPIPA525649)

Supplier: Thermo Scientific

Description: Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions.

Catalog Number: (CAPIPA5-18520)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, feline, mouse, porcine and rat based on sequence homology. The neurotransmitter serotonin exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system . The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.

Catalog Number: (CAPIPA5-18955)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse and porcine based on sequence homology. This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.

Catalog Number: (CAPI21724)

Supplier: Thermo Scientific

Description: Use to develop in-house non-radioactive assay systems.

SDS

Catalog Number: (CAPIPA5-18467)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine and rat based on sequence homology. This gene encodes a member of the tetratrico peptide repeat family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene.

Catalog Number: (CAPIPA5-18797)

Supplier: Thermo Scientific

Description: Recommended Dilutions: Western Blot: 0.1-0.3 ug/ml

Catalog Number: (CAPIPA5-13386)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse based on sequence homology. PARP1 is a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Catalog Number: (CAPIPA526129)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse based on sequence homology. DIPA functions as a transcriptional repressor. It may inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. It may function in adipocyte differentiation, negatively regulating mitotic clonal expansion.

Catalog Number: (CAPIPA5-18318)

Supplier: Thermo Scientific

Description: This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.