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Anti-GATA6 Mouse Monoclonal Antibody [clone: 2F10G3]

Catalog Number: (10169-434)

Supplier: Genetex

Description: Mouse Monoclonal Antibody [2F10G3] to GATA6

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Anti-CD274 Goat Polyclonal Antibody

Catalog Number: (89297-834)

Supplier: Genetex

Description: Goat polyclonal antibody to PD-L1

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Anti-ERF Rabbit Polyclonal Antibody

Catalog Number: (89355-426)

Supplier: Genetex

Description: Rabbit Polyclonal antibody to eRF1 (eukaryotic translation termination factor 1)

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Anti-DNMT2 Mouse Monoclonal Antibody [clone: 102B1259.2]

Catalog Number: (89359-894)

Supplier: Genetex

Description: Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2Fbinding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells.

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Anti-RAC Mouse Monoclonal Antibody [clone: 23A8]

Catalog Number: (89359-564)

Supplier: Genetex

Description: RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.