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Anti-HCV NS3 Mouse Monoclonal Antibody

Catalog Number: (89360-494)

Supplier: Genetex

Description: HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non-structural proteins necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha.

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Anti-IL28RA Goat Polyclonal Antibody

Catalog Number: (89360-466)

Supplier: Genetex

Description: IL28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB. There are 4 isoforms as result of alternative splicing. It is widely expressed. IL28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain.

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Anti-SLC16A7 Goat Polyclonal Antibody

Catalog Number: (89297-996)

Supplier: Genetex

Description: Goat polyclonal antibody to SLC16A7 / MCT2

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Anti-STUB1 Goat Polyclonal Antibody

Catalog Number: (89298-030)

Supplier: Genetex

Description: Goat polyclonal antibody to STUB1 / CHIP

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Anti-ING2 Goat Polyclonal Antibody

Catalog Number: (89298-242)

Supplier: Genetex

Description: Goat polyclonal antibody to ING2 / ING1L

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Anti-EP300 Mouse Monoclonal Antibody [clone: 3G230]

Catalog Number: (89360-078)

Supplier: Genetex

Description: p300 is a transcriptional adapter protein (300 kDa) which is characterized by three cysteine and histidine rich regions and its C-terminus specifically binds the adenovirus E1A protein. p300 and p300 associated proteins are components of TATA-binding protein (TBP) complexes. Protein kinase A mediated CREB phosphorylation results in the binding of CREB to a 265 kDa nuclear protein designated CBP (for CREB-binding protein). CBP and p300 are homologous to each other.

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Anti-RNF2 Goat Polyclonal Antibody

Catalog Number: (89360-062)

Supplier: Genetex

Description: The Polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators, such as Hox genes, and thus are essential for proper development. Changes in expression of PcG proteins have been associated with cancer, while targeted deletions of members of this family generally have lethal phenotypes. Two-hybrid and immunoprecipitation studies have found that the PcG proteins form at least two large nonoverlapping protein complexes. The first type of complex, known as class I, contains homologues of the drosophila proteins esc and E(z) and has been shown to associate with histone deacetylase activity. The second type of complex (class II) includes homologues of Pc, Psc, Ph, Ring, and Scm. No enzymatic activity has been ascribed to this second group of proteins.

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Anti-NCL Mouse Monoclonal Antibody [clone: 4i51]

Catalog Number: (89360-074)

Supplier: Genetex

Description: Nucleolin, which is identical to human DNA helicase IV, is a major nucleolar phosphoprotein which is associated with preribosomal RNA and is implicated in the early stage of preribosomal RNP assembly and processing. This 100 kDa protein has three major domains: a N-terminal domain comprised of long acidic stretches interspersed with basic repeats, similar to the structure of a high mobility group-type protein (this domain is responsible for the ablility of nucleolin to modulate chromatin condensation), a central domain that contains four RNA binding elements, a C-terminal domain approximately 85 amino acids long that is rich in glycine, arginine, and phenylalanine residues. Nucleolin fluctuates in parallel to DNA synthesis; intact 100 kDa protein is the major species in actively dividing cells, whereas the degraded forms are relativley abundant in nondividing cells. Nucleolin can unwind RNA-RNA duplexes, as well as DNA-DNA and DNA-RNA duplexes. Nucleolin also interacts directly with DNA topoisomerase I. It is located mainly in dense fibrillar regions of the nucleolus. Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and preribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. It interacts with APTX and contains 4 RNA recognition motif (RRM) domains.

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Anti-CORO1A Goat Polyclonal Antibody

Catalog Number: (89360-066)

Supplier: Genetex

Description: Coronin 1 was first isolated from Dictyostelium, but similar proteins have been identified in many species and individual cell types. The coronin-like protein in yeast promotes actin polymerization and also interacts with microtubules. Dictyostelium mutants lacking coronin are impaired in cytokinesis and all actin-mediated processes. Analysis of coronin-GFP (green-fluorescent protein) fusions and knockout mutants shows that coronin participates in the remodelling of the cortical actin cytoskeleton that is responsible for phagocytosis and macropinocytosis. Likewise, in mammalian neutrophils, a coronin-like protein is also associated with the phagocytic apparatus. Coronin 1 binds actin (by similarity) and is found in noninfected macrophages, localised to the cortical microtubule network; in mycobacteria-infected macrophages, progressively relocalized and retained around the mycobacterial phagosomes. Coronin1/TACO is expressed in brain, thymus, spleen, bone marrow and lymph node. Low expression observed in lung and gut.