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Product Image-10789-126

Human Recombinant Oncostatin M (from E. coli)

Description: Oncostatin M (OSM) is a cytokine that is produced by macrophages, dendritic cells, and T lymphocytes during inflammatory events. The Type-I and Type-II OSM receptors are located on the cell surface of endothelial and tumor cells, contain the glycoprotein 130 (gp130) subunit, and activate the JAK/STAT signaling pathway. OSM functions to inhibit tumor cell proliferation, induce liver stem cell maturation, regulate cytokine production during hematopoiesis and inflammation, stimulate bone formation, and promote nervous system development.
Catalog Number: 10789-126
Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

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Product Image-10787-540

Human Recombinant IGF-I (from E. coli)

Description: Insulin-like growth factor I (IGF-I) is a growth factor that is produced by the liver. IGF-1 production is stimulated by growth hormone (GH). IGF-I binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-I is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death. Mature human IGF-I is 100% homologous to bovine and porcine IGF-1 proteins.
Catalog Number: 10787-540
Supplier: FUJIFILM IRVINE SCIENTIFIC, INC
Product Image-77705-778

Production Boost Additive (PBA)

Description: Expression Systems’ Production Boost Additive (PBA) is a nutrient boost designed to increase protein expression by supporting the increased needs of insect cells infected by recombinant baculovirus. PBA is a serum-free, animal-free formulation that complements ESF 921 and ESF AF insect cell culture media and extends the late and very-late expression period of production by maintaining high culture viability. PBA is a cocktail of nutrients designed for supplementation at a rate of 1 to 10% at 6 to 36 hours post infection.
Catalog Number: 77705-778
Supplier: EXPRESSION SYSTEMS LLC

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Product Image-CA89235-010

AccuStart™ II PCR Genotyping Kit, Quantabio

Description: The AccuStart™ II PCR Genotyping Kit is designed for fast and easy preparation of PCR-ready DNA extracts and endpoint PCR analysis from tissues such as tail snips and ear punches commonly used for genotyping knockout and transgenic animals
Catalog Number: CA89235-010
Supplier: Quantabio
Product Image-77531-218

Cage-Klenz® 100 Alkaline Detergents

Description: Cage-Klenz® 100 Detergent is a liquid, phosphate-free detergent for use in high pressure spray animal cage washing equipment. It is formulated with corrosion inhibitors for enhanced materials compatibility.
Catalog Number: 77531-218
Supplier: Steris

SDS Certificates New Product


Product Image-10095-614

Anti-MAPT Rabbit Polyclonal Antibody

Description: The microtubule-associated protein TAU (MAPT or TAU) is encoded by MAPT gene, which locates on human chromosome 17q21, binds to the tubulin subunit of microtubule and promotes its assembly and stability. Most TAU is expressed in neurons, and TAU isoform is expressed in the peripheral nervous system while the others are expressed in the central nervous system. TAU links axonal microtubules with C-terminus to neural plasma membrane components with its N-terminus, suggesting the participation in intracellular signal transduction and neuron's development and viability. Present polyclonal anti-MAPT antibody was produced by immunizing animals with N-terminal of MAPT and can detect approx 70-kDa and 100-kDa bands in brain tissues.
Catalog Number: 10095-614
Supplier: Proteintech
Product Image-77975-390

BalanCD™ CHO Feed 3

Description: BalanCD™ CHO Feed 3 is a chemically-defined feed supplement of non-animal origin. Using Irvine Scientific’s Rational Culture Media Design® approach, this formulation has been developed to achieve high growth kinetics and product yield in fed-batch processes. The feed supplement contains balanced concentrations of glucose, amino acids, vitamins and trace elements to provide nutrients to leaner batch media that are needed to boost the productivity of the cell culture system in fed-batch.
Catalog Number: 77975-390
Supplier: FUJIFILM IRVINE SCIENTIFIC INC.

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Image Unavailable-77438-554

Anti-MGLUR5 Rabbit Polyclonal Antibody

Description: Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: Ionotropic receptors, and metabotropic receptors (mGluRs). Metabotropic Glutamate Receptor 5b (GRM5) activity is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The metabotropic glutamate receptor type 5 (mGlu5) is expressed in two splice variants, mGlu5a and mGlu5b, which differ in that mGlu5b has a 33-amino acid insert in the intracellular C-terminal domain. This receptor subtype is highly regulated, with higher levels found in developing animals.
Catalog Number: 77438-554
Supplier: Bioss
Image Unavailable-10397-870

Anti-VP3 Goose parvovirus Rabbit Polyclonal Antibody

Description: Parvoviruses cause infections in a wide variety of goose, Duck, birds and mammals. Parvovirus, commonly called parvo, is a genus of the Parvoviridae family linear, non-segmented single stranded DNA viruses with an average genome size of 5 kbp. Parvoviruses are some of the smallest viruses found in nature. Parvoviruses require actively reproducing cells in order to replicate, the type of tissue infected varies by the age of the animal. The gastrointestinal tract and lymphatic system can be affected at any age, leading to vomiting, diarrhea and immunosuppression.
Catalog Number: 10397-870
Supplier: Bioss
Product Image-MSPP-781362

Human Recombinant EGF, ACF

Description: Epidermal growth factor (EGF) is characterized by high-affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter and Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands, is found in a variety of body fluids, and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright <i>et al.</i>). Central nervous system stem cells also proliferate in response to the EGF stimulus (Reynolds and Weiss). This product is animal component-free.
Catalog Number: MSPP-781362
Supplier: STEMCELL Technologies

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Image Unavailable-10073-050

Human Recombinant NGF beta (from E. coli)

Description: Beta-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Beta-NGF is a potent neurotrophic factor that signals through its receptor Beta-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Beta-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human Beta-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (238 total amino acid residues). The three disulfide bonds are required for biological activity.Manufactured using all non-animal reagents.
Catalog Number: 10073-050
Supplier: Prosci
Product Image-76532-446

Short™ AE-IGF-1 Human Insulin Like Growth Factor

Description: Short™ AE-IGF-1 is a recombinant protein of human insulin-like growth factor-I (IGF-1) that has been engineered with an N-terminal Ala-Glu sequence, enabling higher specific activity versus IGF-1 over a longer time course in small to large-scale culture systems and bioreactors. It is approximately 100-fold more biologically potent, in-vitro, than insulin and significantly increases recombinant protein production while reducing apoptosis. Short™ AE-IGF-1 is produced and tested under ISO 9001, ISO 14001, ISO 45001 accreditation, fully defined animal-free components. It is liquid stable, high purity with requisite performance at a compelling price.
Catalog Number: 76532-446
Supplier: CELLRX LIMITED
Product Image-10088-418

Anti-HOXD13 Rabbit Polyclonal Antibody

Description: HOXD13, also named as HOX4I, belongs to the Abd-B homeobox family. HOXD13 is a sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Mutation of HOXD13 will cause synpolydactyly (SPD), brachydactyly type D (BDD), syndactyly type 5brachydactyly-syndactyly syndrome (BDSD) or brachydactyly type E (BDE).Present polyclonal anti-HOX13D antibody(18736-1-AP) is produced by immunizing animals with part of N-terminus chain of HOX13D and detect a 36-kDa band in cell and tissues.
Catalog Number: 10088-418
Supplier: Proteintech
Product Image-10075-484

Anti-GRIN2B Rabbit Polyclonal Antibody

Description: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression.
Catalog Number: 10075-484
Supplier: Prosci
Product Image-MSPP-781101006

Human/Mouse Recombinant GDF-11

Description: Growth differentiation factor 11 (GDF-11) is a member of transforming growth factor beta (TGF-β) family. It binds to the TGF-β receptors ALK4, ALK5, and ALK7 and activates the SMAD signaling pathway (Ho <i>et al.</i>). GDF-11 regulates the development of the olfactory system, retina, and pancreas, as well as anterior/posterior patterning of the axial skeleton (Lee and Lee). GDF-11 is an endocrine factor expressed in skeletal muscle, brain, and dental pulp (Kondás <i>et al.</i>). Studies in mice showed that GDF-11 regulates muscle and cardiac aging, and stimulates neurogenesis by remodeling blood vessels (Katsimpardi <i>et al.</i>; Loffredo <i>et al.</i>; Sinha <i>et al.</i>). This product is animal component-free.
Catalog Number: MSPP-781101006
Supplier: STEMCELL Technologies

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Image Unavailable-10774-326

Mouse Recombinant Sonic (from E. coli)

Description: Members of the Hedgehog (Hh) family are highly conserved proteins that are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh), are structurally related, and share a high degree of amino acid sequence identity (e.g. Shh and Ihh are 93% identical). The biologically active form of each Hh molecule is obtained by autocatalytic cleavage of their precursor proteins, and each corresponds to approximately one half of the N-terminal portion of the precursor molecule. Although Hh proteins have unique expression patterns and distinct biological roles within their respective regions of secretion, they use the same signaling pathway and can be substituted for one another in experimental systems. Recombinant Murine Sonic Hedgehog (Shh) is a 20.0 kDa protein consisting of 176 amino acid residues, including an N-terminal Ile-Val-Ile sequence substituted for the naturally occurring, chemically modified Cys residue.
Catalog Number: 10774-326
Supplier: Peprotech
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