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Product Image-89416-622

Anti-SLC35D1 Rabbit Polyclonal Antibody

Catalog Number: (89416-622)
Supplier: Prosci
Description: Slc35D1 Antibody: The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.
Product Image-10084-874

Anti-CLOCK Rabbit Polyclonal Antibody

Catalog Number: (10084-874)
Supplier: Proteintech
Description: Circadian locomoter output cycles protein kaput (CLOCK), also named as BHLHE8 or KIAA0334, is a 846 amino acid protein, which contains one bHLH domain, one PAC domain, and two PAS domains. CLOCK localizes in the nucleus and cytoplasm. CLOCK) is expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. ARNTL/2-CLOCK heterodimers activate E-box element (5'-CACGTG-3') transcription of a number of proteins of the circadian clock, such as PER1 and PER2. The calculated molecular weight of CLOCK is 95kDa, but we detected a 150 kDa protein by western blot. Our result is similar to the result of reseach paper .
Product Image-89416-584

Anti-SLC35D1 Rabbit Polyclonal Antibody

Catalog Number: (89416-584)
Supplier: Prosci
Description: Slc35D1 Antibody: The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.
Product Image-89415-628

Anti-XAF1 Rabbit Polyclonal Antibody

Catalog Number: (89415-628)
Supplier: Prosci
Description: XAF-1 Antibody: XAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF-1 results in the neutralization of XIAP's ability to inhibit cell death. XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines. In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF-1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines. Both IFN-alpha2 and IFN-beta can induce XAF-1 mRNA in all cells examined but induction of XAF-1 protein (as observed by immunoblot analysis) was seen only in cell lines sensitive to the apoptotic effects of IFNs.
Product Image-55709-248

VWR®, Accessories for VWR® CryoPro® Rack Systems BR Series

Catalog Number: (55709-248)
Supplier: VWR International
Description: Cryopreservation system, Cryogenic Gloves, Large, Mid-Arm

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Product Image-12574-064

SP Bel-Art Petri Dish Plate Reader, Bel-Art Products, a part of SP

Catalog Number: (12574-064)
Supplier: Bel-Art Products, a Part of SP
Description: This reader allows hands-free viewing of Petri dishes through a large, adjustable mirror with 3× magnification.
Product Image-10749-570

Anti-XAF1 Rabbit Polyclonal Antibody

Catalog Number: (10749-570)
Supplier: Prosci
Description: XAF-1 Antibody: XAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF-1 results in the neutralization of XIAP's ability to inhibit cell death. XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines. In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF-1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines. Both IFN-alpha2 and IFN-beta can induce XAF-1 mRNA in all cells examined but induction of XAF-1 protein (as observed by immunoblot analysis) was seen only in cell lines sensitive to the apoptotic effects of IFNs.
Product Image-89495-446

VWR® Cuff Tape

Supplier: VWR International
Description: This cuff tape is a conformable polyethylene tape used to ensure an effective seal between the glove and garment in cleanroom gowning.

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Product Image-95057-233

VACUETTE® EDTA Tubes, Greiner Bio-One

Supplier: Greiner Bio-One
Description: Designed for use in the examination of whole blood in hematology applications, EDTA tubes feature interior walls that are coated with either K2EDTA or K3EDTA.

Certificates Product available on GSA Advantage®

Image Unavailable-76110-346

Anti-PACRG Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76110-346)
Supplier: Bioss
Description: The deduced 257 amino acid protein PACRG (Parkin co-regulated gene) shows potential links to the ubiquitin/proteasome system. PACRG and Parkin are attached in a head-to-head arrangement on opposite DNA strands and share a common 5' flanking promoter region. The PACRG gene maps to chromosome 6q26; Northern blot analysis detects PACRG expression in all tissues examined except placenta. Using a positional cloning strategy in 197 Vietnamese leprosy simplex families (i.e. families with two unaffected parents and one affected child), significant connections between leprosy and 17 markers in the 5' regulatory region that PARK2 and PACRG share were observed. Possession of two or more of the 17 risk alleles is highly predictive of leprosy.PACRG is a gene located very close to parkin, in reverse orientation on the chromosome. It is thought to be co-transcribed with parkin by a bi-directional promoter between the two genes.
Product Image-89416-904

Anti-TMEM18 Rabbit Polyclonal Antibody

Catalog Number: (89416-904)
Supplier: Prosci
Description: TMEM18 Antibody: Recent studies have examined how overexpression of certain genes enhances the tropism of neural stem cells (NSCs) for gliomas. Overexpression of Transmembrane protein 18 (TMEM18) provides NSCs and neural precursors an increased migration capacity towards glioblastoma cells in vitro and in the rat brain, while functional inactivation of the gene resulted in an almost complete loss of migration activity, suggesting that TMEM18 could be a potential target in NSC-based glioma therapy. Other recent results suggest that among others, the TMEM18 loci is associated with higher than normal body mass index (BMI) and obesity, indicating there may be a CNS-related role in predisposition to obesity. Multiple isoforms of TMEM18 are known to exist.
Product Image-470326-260

DMI® Reusable Underpads

Catalog Number: (470326-260)
Supplier: HEALTH SMART SE
Description: Protect bedding and furniture from moisture.
Product Image-95057-171

VACUETTE® Sodium Citrate Coagulation Tubes, Greiner Bio-One

Supplier: Greiner Bio-One
Description: Designed for use in the examination of coagulation parameters, coagulation tubes contain a buffered tri-sodium citrate solution.

Certificates Product available on GSA Advantage®

Image Unavailable-76376-440

VWR® Cryogenic Dot Label Set

Catalog Number: (76376-440)
Supplier: VWR International
Description: Cryogenic labels are made of a thermoplastic film that is coated with a glove-friendly cryogenic adhesive.
Image Unavailable-10670-462

Anti-PACRG Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10670-462)
Supplier: Bioss
Description: The deduced 257 amino acid protein PACRG (Parkin co-regulated gene) shows potential links to the ubiquitin/proteasome system. PACRG and Parkin are attached in a head-to-head arrangement on opposite DNA strands and share a common 5' flanking promoter region. The PACRG gene maps to chromosome 6q26; Northern blot analysis detects PACRG expression in all tissues examined except placenta. Using a positional cloning strategy in 197 Vietnamese leprosy simplex families (i.e. families with two unaffected parents and one affected child), significant connections between leprosy and 17 markers in the 5' regulatory region that PARK2 and PACRG share were observed. Possession of two or more of the 17 risk alleles is highly predictive of leprosy.PACRG is a gene located very close to parkin, in reverse orientation on the chromosome. It is thought to be co-transcribed with parkin by a bi-directional promoter between the two genes.
Image Unavailable-10670-466

Anti-PACRG Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10670-466)
Supplier: Bioss
Description: The deduced 257 amino acid protein PACRG (Parkin co-regulated gene) shows potential links to the ubiquitin/proteasome system. PACRG and Parkin are attached in a head-to-head arrangement on opposite DNA strands and share a common 5' flanking promoter region. The PACRG gene maps to chromosome 6q26; Northern blot analysis detects PACRG expression in all tissues examined except placenta. Using a positional cloning strategy in 197 Vietnamese leprosy simplex families (i.e. families with two unaffected parents and one affected child), significant connections between leprosy and 17 markers in the 5' regulatory region that PARK2 and PACRG share were observed. Possession of two or more of the 17 risk alleles is highly predictive of leprosy.PACRG is a gene located very close to parkin, in reverse orientation on the chromosome. It is thought to be co-transcribed with parkin by a bi-directional promoter between the two genes.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • issued document with your organization's Federal Tax ID Number
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