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Product Image-10208-470

Anti-CTLA4 Armenian Hamster Monoclonal Antibody (PE (Phycoerythrin)-Cy7®) [clone: UC10-4F10-11]

Description: The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.
Catalog Number: 10208-470
Supplier: Tonbo Biosciences
Image Unavailable-10794-376

Anti-IL10 Rat Monoclonal Antibody [clone: 12G8] (Biotin)

Description: Rat monoclonal antibody [12G8] to IL10
Catalog Number: 10794-376
Supplier: Genetex
Product Image-15715-127

U-tek® Gel Packs, Phase Change Material Gel Packs, Sonoco ThermoSafe

Description: U-TEK® phase change materials (PCM) are formulated refrigerant gel packs for products that require frozen temperatures, but cannot tolerate dry ice or CO<sub>2</sub>.
Catalog Number: 15715-127
Supplier: Sonoco Thermosafe
Product Image-10051-310

Anti-CTLA4 Armenian Hamster Monoclonal Antibody (PE (Phycoerythrin)) [clone: UC10-4F10-11]

Description: The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.
Catalog Number: 10051-310
Supplier: Tonbo Biosciences
Product Image-89417-718

Anti-WIZ Rabbit Polyclonal Antibody

Description: WIZ Antibody: WIZ, also known as ZNF803, was initially identified in a mouse cerebellum cDNA library screen and its message was found to be expressed in the granule cell layers of the cerebellum as well as in the dentate gyrus and olfactory bulb. Later analysis indicates however that WIZ is ubiquitously expressed. WIZ is a nuclear protein that co-localizes with G9a, a histone methyltransferase responsible for mono- and dimethylation of H3K9 at euchromatic regions. WIZ can also associate with CtBP family proteins, known to be transcriptional co-repressors, and has been suggested to link G9a/GLP complexes to the CtBP co-repressor machinery, possibly regulating complex stability and gene silencing.
Catalog Number: 89417-718
Supplier: Prosci
Image Unavailable-76143-726

Premium Industrial Multi-Use Pocket Pants, Dickies®

Description: Dickies® style 211-2272, relaxed fit, straight leg.
Catalog Number: 76143-726
Supplier: Dickies
Image Unavailable-77440-684

Anti-DNAJC21 Rabbit Polyclonal Antibody

Description: May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA.
Catalog Number: 77440-684
Supplier: Bioss
Image Unavailable-75969-154

Anti-TP53 Mouse Monoclonal Antibody [clone: TRP/816]

Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Catalog Number: 75969-154
Supplier: Biotium
Image Unavailable-75980-788

Anti-TP53 Mouse Monoclonal Antibody (Biotin) [clone: Clone PAb122]

Description: PAb122 binds to the C-terminus (aa370-378) of both wild type and mutated p53. When microinjected into nuclei, PAb122 blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 Binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. p53 Is the most commonly mutated gene in spontaneously occurring human cancers. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation.
Catalog Number: 75980-788
Supplier: Biotium
Product Image-47750-988

SP Bel-Art Secador® 2.0, 3.0, 4.0 Auto-Desiccator Cabinets, Bel-Art Products, a part of SP

Description: Protecting valuable humidity-sensitive items, such as reagents or electronics, is easy and fully automatic with Secador® Auto-Desiccator Cabinets.
Catalog Number: 47750-988
Supplier: Bel-Art Products, a Part of SP
Image Unavailable-CA101319-262

E.Z.N.A.® RNA Isolation Kits, Omega Bio-Tek

Description: Isolated RNA can be used for Northern blotting, RT-PCR, nuclease protection assays, in vitro translation, and microarray analysis
Catalog Number: CA101319-262
Supplier: Omega Bio-Tek
Image Unavailable-75969-092

Anti-TP53 Mouse Monoclonal Antibody (Biotin) [clone: BP53-12 DO-7]

Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Catalog Number: 75969-092
Supplier: Biotium
Product Image-10861-014

Absorb-&-Lock® Bio-Fluids Absorbent, PIG®

Description: Permanently solidifies to lock in absorbed liquids so they won't leak or liquify when the absorbents are handled or placed under pressure.
Catalog Number: 10861-014
Supplier: New Pig

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Image Unavailable-77561-496

Human Recombinant PI3K (p110 delta/p85 alpha, His tag), Active (from Baculovirus-Insect Cells)

Description: Recombinant full length human p110 delta and human p85 alpha were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins.
Catalog Number: 77561-496
Supplier: Sino Biological

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Product Image-10105-390

Anti-HIF1AN Rabbit Polyclonal Antibody

Description: HIF1AN is a co-repressor that interacts with hypoxia-inducible factor 1 (HIF-1) alpha and the von Hippel-Lindau tumor suppressor protein to mediate repression of HIF-1 transcriptional activity.
Catalog Number: 10105-390
Supplier: Prosci
Product Image-10106-424

Anti-SIN3B Rabbit Polyclonal Antibody

Description: Sin3B is one of the Sin3 co-repressors act as a protein scaffold to recruit transcription factors via its four highly homologous paired amphipathic helix (PAH) domains.
Catalog Number: 10106-424
Supplier: Prosci
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