You Searched For: Iron+(II)+sulphide

Description: In recent years several groups have studied the sequence requirements, specificity, signaling pathways and kinetics of the TLR (Toll-like receptor) 9 suppression by inhibitory oligonucleotide motifs, which led to a class of novel inhibitory oligonucleotide (iODNs), that is independent of the previously thought species preference. Subsequently it has been discovered that telomeric DNA repeats (TTAGGG)n can block immune activation by CpG-ODNs. Short, 11-15 base long oligonucleotides were synthesized that were capable of potently inhibiting CpG-stimulation. The optimal inhibitory DNA motif consists of a pyrimidine-rich triplet, preferably CCT, which is positioned 5- to the GGG sequence in a singlestranded DNA molecule. Additionally, both the optimal spacing between the CCT and GGG motifs, as well as their relative order to each other, is of crucial importance for the inhibitory DNA action. Interestingly, although both TLR7/TLR8 ligands and bacterial DNA share the endosomal compartment for receptor binding and signal transduction, certain iODNs (G-type) suppress only TLR9-mediated activation, whereas prototype class I iODN may also interfere with the activation via the TLR7/TLR8 pathway. Recently, intriguing evidence has been presented that for some iODN classes the immuno-modulatory biological activity shows only limited sequence dependency or may not even involve TLR-mediated uptake and signaling pathways. For example iODNs of the class II are thought to act on immune activation through inhibition of STAT signaling and independent of TLR signaling via binding to a yet to be identified 'ODN-receptor'. Slightly modified phosphodiester versions of the most potent inhibitory ODNs were also able to profoundly block the immune activation of macrophages and just recently prove to be valuable tools for in vivo use in experimental animal models of inflammatory and auto-immune diseases. Based upon these recent insights the following classification for iODNs has been suggested: Class I: G-stretch ODNs: TLR9-specific competitors, some iODNs may also affect TLR7 and TLR8 signalingClass II: ODNs with telomeric repeats: TLR-independent inhibitors of STAT signaling (cellular uptake via an 'ODN receptor'?)Class III: Inhibitors of DNA uptake in a sequence independent mannerClass IV: Long phosphorothioate ODNs as direct competitors of TLR9 signaling in a sequence independent manner

Catalog Number: 102981-408

Supplier: Adipogen

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Description: G0S2 is a 103 amino acid novel target of peroxisome proliferator-activated receptors (PPARs) and regulator of latent HIV. G0S2 may be involved in adipocyte differentiation and its expression is essential for committing cells to enter the G1 phase of the cell cycle. G0S2 contains a CpG-rich island and multiple sites for potential phosphorylation by casein kinase II and protein kinase C. The gene encoding G0S2 maps to human chromosome 1, which is the largest human chromosome. Chromosome 1 spans about 260 million base pairs and makes up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

Catalog Number: 10664-200

Supplier: Bioss

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Description: For Benches 72 inchWide (Placed Above Or Below The Work Surface)

Catalog Number: VF-ALSFP72

Supplier: VWR International

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Description: Upright freezers with 1-, 2-, or 3-doors, these freezers maintain –10 °F (–23.3 °C).

Catalog Number: 75876-102

Supplier: VWR International

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Description: APHA for BOD (biological oxygen demand).

Catalog Number: BDH7345-1

Supplier: VWR International

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Description: High-impact polystyrene rack has holes to fit 72 pegs.

Catalog Number: 60996-012

Supplier: VWR International

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Description: These HDPE coated wire racks are durable for transport or sample handling.

Catalog Number: 76358-660

Supplier: VWR International

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Description: Slotted uprights allow for easy attachment of Sovella workstation accessories to Sovella benches.

Catalog Number: 77463-256

Supplier: VWR International

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Catalog Number: 97017-648

Supplier: VWR International

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Description: Includes an extra wire frame shelf made to fit VWR® Performance and Plus Series Laboratory units.

Catalog Number: 76520-112

Supplier: VWR International

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Description: Includes an extra wire frame shelf made to fit VWR® Performance and Plus Series Chromatography units.

Catalog Number: 76520-074

Supplier: VWR International

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Description: Swinging or sliding doors. These upright laboratory refrigerators maintain an average temperature of 3 – 5 °C (37 – 41 °F).

Catalog Number: 10018-866

Supplier: VWR International

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Description: Includes an extra wire frame shelf made to fit VWR® stainless steel upright units.

Catalog Number: 76520-138

Supplier: VWR International

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Description: Includes an extra wire frame shelf made to fit VWR® Standard Series Laboratory units.

Catalog Number: 76520-132

Supplier: VWR International

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Description: Swing door, upright laboratory chromatography refrigerators maintain an average temperature of 2 to 8 °C (35.6 to 46.4 °F)

Catalog Number: 10018-868

Supplier: VWR International

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Description: Includes an extra wire frame shelf made to fit VWR® Standard Series Chromatography units.

Catalog Number: 76520-092

Supplier: VWR International

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