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Image Unavailable-76085-710

Anti-Ketohexokinase Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76085-710)
Supplier: Bioss
Description: KHK encodes the gene ketohexokinase that catalyzes conversion of fructose to fructose 1 phosphate. The splice variant presented encodes the highly active form found in liver, renal cortex, and small intestine, while the alternate variant encodes the lower activity form found in most other tissues.
Image Unavailable-103318-826

Anti-MMP-12 Mouse Monoclonal Antibody [clone: 706F9.01]

Catalog Number: (103318-826)
Supplier: Novus Biologicals
Description: The MMP-12 Antibody (706F9.01) from Novus Biologicals is a mouse monoclonal antibody to MMP-12. This antibody reacts with human. The MMP-12 Antibody (706F9.01) has been validated for the following applications: ELISA, Immunohistochemistry, Immunoprecipitation, Immunohistochemistry-Paraffin.
Image Unavailable-103359-520

Anti-IKK beta Mouse Monoclonal Antibody (HRP (Horseradish Peroxidase)) [clone: 10A9B6]

Catalog Number: (103359-520)
Supplier: Novus Biologicals
Description: The IKK beta Antibody (10A9B6) [HRP] from Novus Biologicals is a mouse monoclonal antibody to IKK beta. This antibody reacts with human, mouse. The IKK beta Antibody (10A9B6) [HRP] has been validated for the following applications: Western Blot.
Image Unavailable-75794-302

Human Recombinant NMNAT1 (highly active) (from E. coli)

Catalog Number: (75794-302)
Supplier: Prosci
Description: Nuclear NMNAT isoform. Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. Interacts with PARP-1/ARTD1. Protects against axonal degeneration following mechanical or toxic insults. Widely expressed.
Product Image-10782-370

Anti-ATPase Rabbit Polyclonal Antibody

Catalog Number: (10782-370)
Supplier: Biosensis
Description: CATALYTIC ACTIVITY: ATP + H2O = ADP + phosphate. SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein (By similarity). ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. SIMILARITY: Belongs to the cation transport ATPase (P-type) family. Type V subfamily.
Image Unavailable-10472-628

Anti-GAK Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10472-628)
Supplier: Bioss
Description: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.Tissue specificity: Ubiquitous. Highest in testis.
Image Unavailable-103359-662

Anti-RAD18 Mouse Monoclonal Antibody (HRP (Horseradish Peroxidase)) [clone: 79B1048.1]

Catalog Number: (103359-662)
Supplier: Novus Biologicals
Description: The RAD18 Antibody (79B1048.1) [HRP] from Novus Biologicals is a mouse monoclonal antibody to RAD18. This antibody reacts with human. The RAD18 Antibody (79B1048.1) [HRP] has been validated for the following applications: Western Blot.
Image Unavailable-10354-300

Anti-JUN Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10354-300)
Supplier: Bioss
Description: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Image Unavailable-76110-022

Anti-ASB17 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76110-022)
Supplier: Bioss
Description: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B and C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. Members of the ASB family include ASB-1 through ASB-18 and are involved in a variety of biological processes. ASB-17 is a 295 amino acid member of this family. ASB-17 contains one ankyrin repeat and one SOCS box domain. ASB-17 is thought to be a substrate-recognition subunit of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin protein ligase complex. This complex mediates the ubiquitination of target proteins and their subsequent proteasomal degradation.
Image Unavailable-H-4864.0500BA

Human Ghrelin Trifluoroacetate

Supplier: Bachem Americas
Description: Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.

Image Unavailable-10667-770

Anti-ASB17 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10667-770)
Supplier: Bioss
Description: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B and C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. Members of the ASB family include ASB-1 through ASB-18 and are involved in a variety of biological processes. ASB-17 is a 295 amino acid member of this family. ASB-17 contains one ankyrin repeat and one SOCS box domain. ASB-17 is thought to be a substrate-recognition subunit of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin protein ligase complex. This complex mediates the ubiquitination of target proteins and their subsequent proteasomal degradation.
Image Unavailable-75978-412

Anti-TYMS Mouse Monoclonal Antibody (CF568) [clone: TS106]

Supplier: Biotium
Description: This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Image Unavailable-75978-340

Anti-TYMS Mouse Monoclonal Antibody (CF594) [clone: TMS715]

Supplier: Biotium
Description: This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Image Unavailable-103358-686

Anti-PKN1 Rabbit Polyclonal Antibody

Catalog Number: (103358-686)
Supplier: Novus Biologicals
Description: The PKN1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to PKN1. This antibody reacts with human, mouse, rat, canine. The PKN1 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunoprecipitation, Immunohistochemistry-Paraffin.
Image Unavailable-103361-082

Anti-Lck Mouse Monoclonal Antibody (DyLight 350) [clone: 33D196]

Catalog Number: (103361-082)
Supplier: Novus Biologicals
Description: The Lck Antibody (33D196) [DyLight 350] from Novus Biologicals is a mouse monoclonal antibody to Lck. This antibody reacts with human, mouse. The Lck Antibody (33D196) [DyLight 350] has been validated for the following applications: Western Blot.
Image Unavailable-H-5946.1000BA

Human (Des-octanoyl)-Ghrelin Trifluoroacetate

Supplier: Bachem Americas
Description: Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.

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