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Description: Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.

Catalog Number: 10068-630

Supplier: Prosci

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Description: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.

Catalog Number: 10431-896

Supplier: Bioss

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Description: Rabbit Polyclonal antibody to NFAT4 (phospho Ser165)

Catalog Number: 10162-864

Supplier: Genetex

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Description: Anti-DNA PKcs pT 2609 antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 460 kDa in size corresponding to DNA PKcs by western blotting.

Catalog Number: CA600-401-494

Supplier: Rockland Immunochemical

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Description: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.

Catalog Number: 10431-914

Supplier: Bioss

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Description: phosphorylated at the Thr-Pro-Tyr phosphorylation motif instead of the characteristic MAP kinase Thr-Glu-Tyr motif. JNK2 (p54a, SAPK1a), along with JNK1 and JNK3, is thought to play an important role in nuclear signal transduction through its environmental stress activation and subsequent phosphorylation of the nuclear transcription factor p53.

Catalog Number: 10416-774

Supplier: Bioss

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Description: phosphorylated at the Thr-Pro-Tyr phosphorylation motif instead of the characteristic MAP kinase Thr-Glu-Tyr motif. JNK2 (p54a, SAPK1a), along with JNK1 and JNK3, is thought to play an important role in nuclear signal transduction through its environmental stress activation and subsequent phosphorylation of the nuclear transcription factor p53.

Catalog Number: 10416-782

Supplier: Bioss

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Description: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Catalog Number: 10813-912

Supplier: Prosci

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Description: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Catalog Number: 10068-776

Supplier: Prosci

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Description: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.

Catalog Number: 10071-442

Supplier: Prosci

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Description: Rabbit polyclonal antibody to H3 (phospho Ser10)

Catalog Number: 10162-722

Supplier: Genetex

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Description: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Catalog Number: 10068-944

Supplier: Prosci

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Description: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.

Catalog Number: 10068-496

Supplier: Prosci

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Description: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).

Catalog Number: 10068-956

Supplier: Prosci

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Description: Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

Catalog Number: 10813-910

Supplier: Prosci

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Description: May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

Catalog Number: 10068-948

Supplier: Prosci

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