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Image Unavailable-76117-728

Anti-RNF139 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76117-728)
Supplier: Bioss
Description: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
Image Unavailable-10494-186

Anti-DENND2C Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10494-186)
Supplier: Bioss
Description: DENND2C is a 928 amino acid protein that contains a dDENN domain, a DENN domain, and a uDENN domain and exists as three isoforms as a result of alternative splicing. The DENND2C protein is thought to target to actin filaments and control Rab9-dependent trafficking of mannose-6-phosphate receptor to lysosomes. The gene encoding DENND2C maps to human chromosome 1, the largest human chromosome which spans about 260 million base pairs and makes up 8% of the human genome. Other notable genes located on chromosome 1 include LMNA, which is associated with the rare aging disease Hutchinson-Gilford progeria, and the MUTYH gene, which is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome.
Image Unavailable-10495-174

Anti-LRCH3 Rabbit Polyclonal Antibody

Catalog Number: (10495-174)
Supplier: Bioss
Description: Members of the leucine-rich repeat family includes LRCH1, LRCH2, LRCH3 and LRCH4. All family members contain one calponin-homology domain and nine leucine-rich repeats. The best characterized leucine-rich repeat family member is LRCH4, which is suggested to be involved in ligand binding in the brain, with expression observed primarily in the hippocampus. As a cell adhesion molecule and signal receptor, LRCH4 may play an important role in maintenance of hippocampus-dependent memories, with defects in the gene possibly contributing to a loss of long-term memory. The gene encoding LRCH3 maps to human chromosome 3, which spans 200 million base pairs and encodes between 1,100 and 1,500 genes. There are three isoforms of LRCH3 that are produced as a result of alternative splicing events.
Image Unavailable-89287-146

Anti-CD20 Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: LT20]

Catalog Number: (89287-146)
Supplier: Genetex
Description: Monoclonal Antibody to CD20 (Human) Allophycocyanin (APC)
Product Image-10108-672

Anti-ALOX15B Rabbit Polyclonal Antibody

Catalog Number: (10108-672)
Supplier: Prosci
Description: ALOX15B is a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively.This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
Image Unavailable-10491-534

Anti-LAPTM4A Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10491-534)
Supplier: Bioss
Description: Lysosomal-associated transmembrane protein 4A (LAPTM4A), also known as Golgi 4-transmembrane spanning transporter MTP, is a 233 amino acid protein belonging to the LAPTM5/LAPTM5 transporter family. LAPTM4A is subcellularly localized to the intracytoplasmic membrane and has the potential to reside in intracellular membrane-bound compartments. LAPTM4A is thought to function as a transporter of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of intracellular compartments. LAPTM4A is predicted to have four transmembrane domains, with the C-terminal domain being required for retention of the protein within intracellular membranes.
Image Unavailable-10794-538

Anti-MS4A6A Rabbit Polyclonal Antibody

Catalog Number: (10794-538)
Supplier: Genetex
Description: Rabbit polyclonal antibody to MS4A6A
Product Image-10813-764

Anti-FGFR1/FGFR2 Rabbit Polyclonal Antibody

Catalog Number: (10813-764)
Supplier: Prosci
Description: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
Image Unavailable-10414-294

Anti-PMVK Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10414-294)
Supplier: Bioss
Description: PMVK is a 192 amino acid peroxisomal enzyme belonging to the nucleoside monophosphate (NMP) kinase family and is expressed in heart, liver, skeletal muscle, kidney, and pancreas with lower expression in brain, placenta and lung. Induced by sterol, PMVK participates in isopentenyl diphosphate biosynthesis via the mevalonate pathway. PMVK catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate in the fifth reaction of the cholesterol biosynthetic pathway. PMVK exists as a monomer and is encoded by a gene located on human chromosome 1, which houses over 3,000 genes and is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.
Product Image-10752-014

Anti-FGFR3 Rabbit Polyclonal Antibody

Catalog Number: (10752-014)
Supplier: Prosci
Description: FGFR3 Antibody: FGFR3 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. It is required for normal skeleton development and promotes apoptosis in chondrocytes and cancer cell proliferation. FGFR3 protein contains three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. It is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR3 are associated with several diseases, including achondroplasia and hypochondroplasia. Mutations in FGFR3 are also a cause of some bladder and cervical cancers.
Image Unavailable-76080-320

Anti-PMVK Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76080-320)
Supplier: Bioss
Description: PMVK is a 192 amino acid peroxisomal enzyme belonging to the nucleoside monophosphate (NMP) kinase family and is expressed in heart, liver, skeletal muscle, kidney, and pancreas with lower expression in brain, placenta and lung. Induced by sterol, PMVK participates in isopentenyl diphosphate biosynthesis via the mevalonate pathway. PMVK catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate in the fifth reaction of the cholesterol biosynthetic pathway. PMVK exists as a monomer and is encoded by a gene located on human chromosome 1, which houses over 3,000 genes and is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.
Product Image-10106-518

Anti-ANXA5 Rabbit Polyclonal Antibody

Catalog Number: (10106-518)
Supplier: Prosci
Description: ANXA5 belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.
Image Unavailable-10491-512

Anti-LAPTM4A Rabbit Polyclonal Antibody

Catalog Number: (10491-512)
Supplier: Bioss
Description: Lysosomal-associated transmembrane protein 4A (LAPTM4A), also known as Golgi 4-transmembrane spanning transporter MTP, is a 233 amino acid protein belonging to the LAPTM5/LAPTM5 transporter family. LAPTM4A is subcellularly localized to the intracytoplasmic membrane and has the potential to reside in intracellular membrane-bound compartments. LAPTM4A is thought to function as a transporter of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of intracellular compartments. LAPTM4A is predicted to have four transmembrane domains, with the C-terminal domain being required for retention of the protein within intracellular membranes.
Image Unavailable-TCD1118-001G

9-(4'-Dimethylaminophenyl)-2,6,7-trihydroxyfluorone sulfate hydrate ≥95.0% (by HPLC)

Catalog Number: (TCD1118-001G)
Supplier: TCI America
Description: CAS Number: 71501-19-4
MDL Number: MFCD00035151
Molecular Formula: C21H17NO5
Purity/Analysis Method: >95.0% (HPLC)
Form: Crystal

SDS


Product Image-89415-528

Anti-KLHL1 Rabbit Polyclonal Antibody

Catalog Number: (89415-528)
Supplier: Prosci
Description: KLHL1 Antibody: The mammalian Kelch-like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin-organizing proteins. Based on the presence of anti-sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.
Image Unavailable-75917-202

Anti-CD6 Mouse Monoclonal Antibody [clone: C6/372]

Catalog Number: (75917-202)
Supplier: Biotium
Description: CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellularscavenger receptor cysteine-rich(SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.
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