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Image Unavailable-77439-956

Anti-SOD2 Rabbit Polyclonal Antibody

Catalog Number: (77439-956)
Supplier: Bioss
Description: This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Image Unavailable-CA1.16982.0001

Accessories for Reflectoquant® Analysis System, MilliporeSigma

Catalog Number: (CA1.16982.0001)
Supplier: MilliporeSigma
Description: MilliporeSigma # 1.16128.0001 replaces and is identical to MilliporeSigma # 16128-1.
MilliporeSigma # 1.16720.0001 replaces and is identical to MilliporeSigma # 16720-1.
MilliporeSigma # 1.16957.0001 replaces and is identical to MilliporeSigma # 1.16957.0007.
MilliporeSigma # 1.16973.0001 replaces and is identical to MilliporeSigma # 16973-1.
MilliporeSigma # 1.16974.0001 replaces and is identical to MilliporeSigma # 16974-1.
MilliporeSigma # 1.16975.0001 replaces and is identical to MilliporeSigma # 16975-1.
MilliporeSigma # 1.16976.0001 replaces and is identical to MilliporeSigma # 16976-1.
MilliporeSigma # 1.16982.0001 replaces and is identical to MilliporeSigma # 16982-1.
MilliporeSigma # 1.16995.0001 replaces and is identical to MilliporeSigma # 16995-1.

Certificates


Image Unavailable-77439-112

Anti-ALKBH5 Rabbit Polyclonal Antibody

Catalog Number: (77439-112)
Supplier: Bioss
Description: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A)RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178,PubMed:24616105, PubMed:24489119). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro)(PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178,PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity).
Image Unavailable-CAAA12523-36

Copper(II) nitrate hemipentahydrate 98.0-102.0% ACS

Supplier: Thermo Scientific Chemicals
Description: Catalyst, nitrating agent for aromatic organosilicon compounds, nickel-plating baths, coloring copper black, and producing a burnished effect on iron

Certificates

Image Unavailable-10481-994

Anti-PANK2 Rabbit Polyclonal Antibody

Catalog Number: (10481-994)
Supplier: Bioss
Description: Defects in PANK2 are the cause of neurodegeneration with brain iron accumulation type 1 (NBIA1); also known as pantothenate kinase-associated neurodegeneration (PKAN) or Hallervorden-Spatz syndrome (HSS). It is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. Clinical manifestations include progressive muscle spasticity, hyperreflexia, muscle rigidity, dystonia, dysarthria, and intellectual deterioration which progresses to severe dementia over several years. It is clinically classified into classic, atypical, and intermediate phenotypes. Classic forms present with onset in the first decade, rapid progression, loss of independent ambulation within 15 years. Atypical forms have onset in the second decade, slow progression, maintenance of independent ambulation up to 40 years later. Intermediate forms manifest onset in the first decade with slow progression or onset in the second decade with rapid progression. Patients with early onset tend to also develop pigmentary retinopathy, whereas those with later onset tend to also have speech disorders and psychiatric features. All patients have the 'eye of the tiger' sign on brain MRI.Defects in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP). HARP is a rare syndrome with many clinical similarities to NBIA1.
Image Unavailable-10482-240

Anti-PANK2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10482-240)
Supplier: Bioss
Description: Defects in PANK2 are the cause of neurodegeneration with brain iron accumulation type 1 (NBIA1); also known as pantothenate kinase-associated neurodegeneration (PKAN) or Hallervorden-Spatz syndrome (HSS). It is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. Clinical manifestations include progressive muscle spasticity, hyperreflexia, muscle rigidity, dystonia, dysarthria, and intellectual deterioration which progresses to severe dementia over several years. It is clinically classified into classic, atypical, and intermediate phenotypes. Classic forms present with onset in the first decade, rapid progression, loss of independent ambulation within 15 years. Atypical forms have onset in the second decade, slow progression, maintenance of independent ambulation up to 40 years later. Intermediate forms manifest onset in the first decade with slow progression or onset in the second decade with rapid progression. Patients with early onset tend to also develop pigmentary retinopathy, whereas those with later onset tend to also have speech disorders and psychiatric features. All patients have the 'eye of the tiger' sign on brain MRI.Defects in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP). HARP is a rare syndrome with many clinical similarities to NBIA1.
Product Image-470163-090

Equilibrium Constant Of An Ionic Compound AP Chemistry Kit

Catalog Number: (470163-090)
Supplier: Ward's Science
Description: Determine The Equilibrium Constant for Colored Species

SDS


Product Image-10102-584

Anti-HAAO Rabbit Polyclonal Antibody

Catalog Number: (10102-584)
Supplier: Prosci
Description: 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
Image Unavailable-89297-696

Anti-SDHB Goat Polyclonal Antibody

Catalog Number: (89297-696)
Supplier: Genetex
Description: Goat polyclonal antibody to SDHB
Image Unavailable-10072-558

Human Recombinant Cho Cell Gdf-2 (from CHO Cells)

Catalog Number: (10072-558)
Supplier: Prosci
Description: GDF-2 belongs to the TGF-B cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-2 is expressed mainly in nonparenchymal cells of the liver, but is also found in other various cells and tissues. GDF-2 can signal through the ALK1 receptor and has been implicated in a number of physiologic events. These include regulation of the hepatic reticuloendothelial system, glucose homeostasis, and iron homeostasis, as well as the inhibition of angiogenesis. Recombinant human GDF-2 is a 24.1 kDa disulfide linked homodimeric protein consisting of two 110 amino acid polypeptide chains.
Image Unavailable-75791-138

Human Recombinant UBE2D1 (from E. coli)

Catalog Number: (75791-138)
Supplier: Prosci
Description: Ubiquitin-conjugating enzyme E2 D1（UBE2D1）belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
Product Image-30000-198

Lead-Insertion Grade Conductive Foam, Protektive Pak®

Catalog Number: (30000-198)
Supplier: Protektive Pak
Description: Ideal for lead insertion packaging, providing ESD and physical protection to component leads.
Product Image-470356-686

Steel Wool

Catalog Number: (470356-686)
Supplier: COOK IRON STORE
Description: Steel wool of size 00.

New Product


Image Unavailable-89267-512

Anti-ISCA2 Rabbit Polyclonal Antibody

Catalog Number: (89267-512)
Supplier: Genetex
Description: Rabbit polyclonal antibody to ISCA2 (Middle)
Image Unavailable-75791-090

Human Recombinant NGAL (from E. coli)

Catalog Number: (75791-090)
Supplier: Prosci
Description: Neutrophil gelatinase-associated lipocalin(LCN2) is a secreted protein and belongs to the calycin superfamily. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.
Image Unavailable-76085-268

Anti-NDUFS1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76085-268)
Supplier: Bioss
Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.
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